Park, Jung Yeon Kim, Jehan Ha, Jeong Sook Kim, Yongju 2024-02-22T02:00:20Z 2024-02-22T02:00:20Z 2024-02-22 2024-02 1944-8244 https://pubs.kist.re.kr/handle/201004/149292 Most supramolecular systems were discovered by using a trial-and-error approach, leading to numerous synthetic efforts to obtain optimal supramolecular building blocks for selective guest encapsulation. Here, we report a simple coassembly strategy for preparing tamoxifen-selective supramolecular nanomaterials in an aqueous solution. The synthetic amphiphile molecule, 1,1,2,2-tetraphenylethylene (TPE), promotes large tamoxifen aggregate disassembly into smaller, discrete aggregates such as ribbon-like and micellar assemblies in coassembled solutions, enhancing the solubility and dispersion. The TPE moiety exhibits enhanced emission upon tamoxifen interaction, enabling the observation of the coassembled species in an aqueous solution for cell imaging. The tamoxifen-selective fluorescent micelles in the presence of a 1:1 molar ratio of TPE derivative with tamoxifen show enhanced tamoxifen absorption and anticancer effects against MCF-7 breast cancer cells. These supramolecular approaches, based on the coassembly of building blocks with molecular structural similarity, can provide a novel strategy for the efficient development of selective molecular carriers with enhanced biological activities. English American Chemical Society Self-Assembled Tamoxifen-Selective Fluorescent Nanomaterials Driven by Molecular Structural Similarity Article 10.1021/acsami.3c14547 1 ACS Applied Materials & Interfaces, v.16, no.5, pp.5462 - 5473 ACS Applied Materials & Interfaces 16 5 5462 5473 N scie scopus 001158593000001 2-s2.0-85184668586 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article PERCUTANEOUS-ABSORPTION ENHANCEMENT DRUG TAMOXIFEN NANOPARTICLES BIOACTIVITY SOLUBILITY DELIVERY supramolecular materials structural similarity fluorescent nanomaterials anticancer activity tamoxifen molecular carriers tetraphenylethylene