Lee, Jae-Hun Kim, Jae-Yoon Ryu, Kanghyun Al-masni, Mohammed A. Kim, Tae Hyung Han, Dongyeob Kim, Hyun Gi Kim, Dong-Hyun 2024-03-07T02:30:14Z 2024-03-07T02:30:14Z 2024-03-07 2024-06 0740-3194 https://pubs.kist.re.kr/handle/201004/149399 Purpose: We introduced a novel reconstruction network, jointly unrolled cross-domain optimization-based spatio-temporal reconstruction network (JUST-Net), aimed at accelerating 3D multi-echo gradient-echo (mGRE) data acquisition and improving the quality of resulting myelin water imaging (MWI) maps. Method: n unrolled cross-domain spatio-temporal reconstruction network was designed. The main idea is to combine frequency and spatio-temporal image feature representations and to sequentially implement convolution layers in both domains. The k-space subnetwork utilizes shared information from adjacent frames, whereas the image subnetwork applies separate convolutions in both spatial and temporal dimensions. The proposed reconstruction network was evaluated for both retrospectively and prospectively accelerated acquisition. Furthermore, it was assessed in simulation studies and real-world cases with k-space corruptions to evaluate its potential for motion artifact reduction. Results: The proposed JUST-Net enabled highly reproducible and accelerated 3D mGRE acquisition for whole-brain MWI, reducing the acquisition time from fully sampled 15:23 to 2:22 min within a 3-min reconstruction time. The normalized root mean squared error of the reconstructed mGRE images increased by less than 4.0%, and the correlation coefficients for MWI showed a value of over 0.68 when compared to the fully sampled reference. Additionally, the proposed method demonstrated a mitigating effect on both simulated and clinical motion-corrupted cases. Conclusion: The proposed JUST-Net has demonstrated the capability to achieve high acceleration factors for 3D mGRE-based MWI, which is expected to facilitate widespread clinical applications of MWI. English John Wiley & Sons Inc. JUST-Net: Jointly unrolled cross-domain optimization based spatio-temporal reconstruction network for accelerated 3D myelin water imaging Article 10.1002/mrm.30021 1 Magnetic Resonance in Medicine, v.91, no.6, pp.2483 - 2497 Magnetic Resonance in Medicine 91 6 2483 2497 Y scie scopus 001161079700001 2-s2.0-85185149555 Radiology, Nuclear Medicine & Medical Imaging Radiology, Nuclear Medicine & Medical Imaging Article FRACTION BRAIN MODEL SENSE accelerating 3D multi-echo gradient-echo deep learning myelin water imaging prospectively accelerated acquisition reproducibility test spatio-temporal reconstruction