Kim, Hoe-In Veeramanoharan, Ashokkumar Selvaraj, Baskar Olivier, Maniriho Lee, Eunji Lee, Jae Wook Park, Chung-Min 2024-03-28T00:30:10Z 2024-03-28T00:30:10Z 2024-03-27 2024-04 0002-7863 https://pubs.kist.re.kr/handle/201004/149531 This study presents a global strategy for the transsulfuration of intracellular thiols (RSH) to persulfides (RSSH). Thiiranes comprising fluorenyl/diphenyl and malonate ester moieties directly convert intercellular RSH to low-molecular-weight RSSH in cells. The efficiency of transsulfuration is determined by counting the number of olefins produced as byproducts, providing ratiometric signals for the corresponding persulfide production. Specifically, the direct and rapid protein S-persulfidation by thiirane is validated. Thiiranes are expected to play a crucial role in the study of sulfur signaling. English American Chemical Society Thiiranes: Intelligent Molecules for S-Persulfidation Article 10.1021/jacs.3c12908 1 Journal of the American Chemical Society, v.146, no.13, pp.8820 - 8825 Journal of the American Chemical Society 146 13 8820 8825 N scie scopus 001189961100001 Chemistry, Multidisciplinary Chemistry Article PRECURSORS PROBES SULFUR HYDROGEN-SULFIDE CYSTEINE PERSULFIDES H2S DISULFIDES REACTIVITY