Cho, Myeongki Han, Jeong-Kyu Suh, Jungmin Kim, Jeong Jin Ryu, Jae Ryun Min, In Sik Sang, Mingyu Lim, Selin Kim, Tae Soo Kim, Kyubeen Kang, Kyowon Hwang, Kyuhyun Kim, Kanghwan Hong, Eun-Bin Nam, Min-Ho Kim, Jongbaeg Song, Young Min Lee, Gil Ju Cho, Il-Joo Yu, Ki Jun 2024-04-11T03:00:04Z 2024-04-11T03:00:04Z 2024-04-11 2024-03 https://pubs.kist.re.kr/handle/201004/149629 Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine. Bioresorbable neural implants offer a promising solution to the challenges of secondary surgeries required for the removal of implanted devices. Here, the authors introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. English Nature Publishing Group Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation Article 10.1038/s41467-024-45803-0 1 Nature Communications, v.15, no.1 Nature Communications 15 1 Y scie scopus 001180826600028 2-s2.0-85187111033 Multidisciplinary Sciences Science & Technology - Other Topics Article OPTICAL CONTROL ELECTRODE ARRAY CIRCUITS SENSORS PROBES