Nguyen, Bao Ngoc Hong, Soyeon Choi, Sowoon Lee, Choong-Gu Yoo, Gy hye Kim, Myung Suk 2024-05-16T01:30:07Z 2024-05-16T01:30:07Z 2024-05-14 2024-05 1226-8453 https://pubs.kist.re.kr/handle/201004/149842 Background Osteosarcopenia is a common condition characterized by the loss of both bone and muscle mass, which can lead to an increased risk of fractures and disability in older adults. The study aimed to elucidate the response of various mouse strains to treatment with Rg3, one of the leading ginsenosides, on musculoskeletal traits and immune function, and their correlation. Methods Six Collaborative Cross (CC) founder strains induced muscle atrophy and bone loss with dexamethasone (15 mg/kg) treatment for 1 month, and half of the mice for each strain were orally administered Rg3 (20 mg/kg). Different responses were observed depending on genetic background and Rg3 treatment. Results Rg3 significantly increased grip strength, running performance, and expression of muscle and bone health-related genes in a two-way analysis of variance considering the genetic backgrounds and Rg3 treatment. Significant improvements in grip strength, running performance, bone area, and muscle mass, and the increased gene expression were observed in specific strains of PWK/PhJ. For traits related to muscle, bone, and immune functions, significant correlations between traits were confirmed following Rg3 administration compared with control mice. The phenotyping analysis was compiled into a public web resource called Rg3-OsteoSarco. Conclusion This highlights the complex interplay between genetic determinants, pathogenesis of muscle atrophy and bone loss, and phytochemical bioactivity and the need to move away from single inbred mouse models to improve their translatability to genetically diverse humans. Rg3-OsteoSarco highlights the use of CC founder strains as a valuable tool in the field of personalized nutrition. English 고려인삼학회 Dexamethasone-induced muscle atrophy and bone loss in six genetically diverse collaborative cross founder strains demonstrates phenotypic variability by Rg3 treatment Article 10.1016/j.jgr.2023.12.004 1 Journal of Ginseng Research, v.48, no.3, pp.310 - 322 Journal of Ginseng Research 48 3 310 322 Y scie scopus kci other 001232681600001 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article MINERAL DENSITY GINSENOSIDE RG3 T-CELLS SARCOPENIA REGENERATION OSTEOPOROSIS SKELETAL-MUSCLE Osteosarcopenia Immune function Precision nutrition Ginsenoside Rg3 Collaborative cross founder strains