Park, Ji-Eun Kim, Dong-Hwee 2024-05-30T08:30:25Z 2024-05-30T08:30:25Z 2024-05-30 2025-02 2192-2640 https://pubs.kist.re.kr/handle/201004/149949 The multifaceted biological defense system modulating complex immune responses against pathogens and foreign materials plays a critical role in tissue homeostasis and disease progression. Recently developed biomaterials that can specifically regulate immune responses, nanoparticles, graphene, and functional hydrogels have contributed to the advancement of tissue engineering as well as disease treatment. The interaction between innate and adaptive immunity, collectively determining immune responses, can be regulated by mechanobiological recognition and adaptation of immune cells to the extracellular microenvironment. Therefore, applying immunomodulation to tissue regeneration and cancer therapy involves manipulating the properties of biomaterials by tailoring their composition in the context of the immune system. This review provides a comprehensive overview of how the physicochemical attributes of biomaterials determine immune responses, focusing on the physical properties that influence innate and adaptive immunity. This review also underscores the critical aspect of biomaterial-based immune engineering for the development of novel therapeutics and emphasizes the importance of understanding the biomaterials-mediated immunological mechanisms and their role in modulating the immune system. Multiple immune cells sequentially responding to specific signaling molecules closely interact with the distinct physicochemical properties of their extracellular microenvironment by tailoring their composition in the context of the immune system. Immunomodulation guided by finely tuned biomaterials further promotes the development of novel therapeutic applications in regenerative tissue engineering and cancer immunotherapy. image English Wiley-Blackwell Advanced Immunomodulatory Biomaterials for Therapeutic Applications Article 10.1002/adhm.202304496 1 Advanced Healthcare Materials, v.14, no.5 Advanced Healthcare Materials 14 5 N scie scopus 001227853800001 2-s2.0-85193592094 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Review FOREIGN-BODY REACTION REGULATORY T-CELLS NEUTROPHIL EXTRACELLULAR TRAPS FIBROBLAST-DERIVED MATRIX GRAPHENE-BASED MATERIALS DRUG-DELIVERY SYSTEMS DENDRITIC CELLS IN-VITRO B-CELLS TISSUE-REPAIR cancer immunotherapy immune system immunomodulation mechano-regulation therapeutics tissue regeneration