Han, Sang Ihn Sunwoo, Sung-Hyuk Park, Chan Soon Lee, Seung-Pyo Hyeon, Taeghwan Kim, Dae-Hyeong 2024-05-30T10:00:20Z 2024-05-30T10:00:20Z 2024-05-30 2024-05 1936-0851 https://pubs.kist.re.kr/handle/201004/149973 Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms of electrophysiological monitoring and implementation of therapies. However, conventional cardiac devices are typically composed of rigid and bulky materials and thus pose significant challenges for effective long-term interfacing with the curvilinear surface of a dynamically beating heart. In this regard, the recent development of intrinsically soft bioelectronic devices using nanocomposites, which are fabricated by blending conductive nanofillers in polymeric and elastomeric matrices, has shown great promise. The intrinsically soft bioelectronics not only endure the dynamic beating motion of the heart and maintain stable performance but also enable conformal, reliable, and large-area interfacing with the target cardiac tissue, allowing for high-quality electrophysiological mapping, feedback electrical stimulations, and even mechanical assistance. Here, we explore next-generation cardiac interfacing strategies based on soft bioelectronic devices that utilize elastic conductive nanocomposites. We first discuss the conventional cardiac devices used to manage cardiovascular diseases and explain their undesired limitations. Then, we introduce intrinsically soft polymeric materials and mechanical restraint devices utilizing soft polymeric materials. After the discussion of the fabrication and functionalization of conductive nanomaterials, the introduction of intrinsically soft bioelectronics using nanocomposites and their application to cardiac monitoring and feedback therapy follow. Finally, comments on the future prospects of soft bioelectronics for cardiac interfacing technologies are discussed. English American Chemical Society Next-Generation Cardiac Interfacing Technologies Using Nanomaterial-Based Soft Bioelectronics Article 10.1021/acsnano.4c02171 1 ACS Nano, v.18, no.19, pp.12025 - 12048 ACS Nano 18 19 12025 12048 N scie scopus 001225082800001 2-s2.0-85192455695 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review VENTRICULAR RESTRAINT THERAPY HEART-FAILURE GLOBAL BURDEN OVINE MODEL ELECTRICAL-CONDUCTIVITY CARDIOVASCULAR-DISEASES ELASTIC CONDUCTORS DEVICE DESIGNS SUPPORT DEVICE MECHANISMS nanomaterials soft nanocomposites cardiovascular diseases implantable bioelectronics soft bioelectronics