Kim, Jihye Bury, Matthew I. Kwon, Kyeongha Yoo, Jae - Young Halstead, Nadia, V Shin, Hee-Sup Li, Shupeng Won, Sang Min Seo, Min-Ho Wu, Yunyun Park, Do Yun Kini, Mitali Kwak, Jean Won Madhvapathy, Surabhi R. Ciatti, Joanna L. Lee, Jae Hee Kim, Suyeon Ryu, Hanjun Yamagishi, Kento Yoon, Hong- Joon Kwak, Sung Soo Kim, Bosung Huang, Yonggang Halliday, Lisa C. Cheng, Earl Y. Ameer, Guillermo A. Sharma, Arun K. Rogers, John A. 2024-06-07T02:00:45Z 2024-06-07T02:00:45Z 2024-06-07 2024-04 0027-8424 https://pubs.kist.re.kr/handle/201004/150018 Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient - friendly, they exhibit user - to - user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter - associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high - risk patients. Here, we introduce a fully bladder - implantable platform that allows for continuous, real - time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real - time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long - term postoperative bladder recovery monitoring. English National Academy of Sciences A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery Article 10.1073/pnas.2400868121 1 Proceedings of the National Academy of Sciences of the United States of America, v.121, no.14 Proceedings of the National Academy of Sciences of the United States of America 121 14 N scie scopus 001222163200002 2-s2.0-85189253299 Multidisciplinary Sciences Science & Technology - Other Topics Article PARTIAL CYSTECTOMY CANCER bladder regeneration bioelectronics wireless sensing