Kwak, Taehwan Park, Si-Hyung Lee, Siyoung Shin, Yujeong Yoon, Ki-Jun Cho, Seung-Woo Park, Jong-Chan Yang, Seung-Ho Cho, Heeyeong Im, Heh-In Ahn, Sun-Ju Sun, Woong Yang, Ji Hun 2024-06-07T05:30:39Z 2024-06-07T05:30:39Z 2024-06-07 2024-05 2005-3606 https://pubs.kist.re.kr/handle/201004/150032 This study offers a comprehensive overview of brain organoids for researchers. It combines expert opinions with technical summaries on organoid definitions, characteristics, culture methods, and quality control. This approach aims to enhance the utilization of brain organoids in research. Brain organoids, as three-dimensional human cell models mimicking the nervous system, hold immense promise for studying the human brain. They offer advantages over traditional methods, replicating anatomical structures, physiological features, and complex neuronal networks. Additionally, brain organoids can model nervous system development and interactions between cell types and the microenvironment. By providing a foundation for utilizing the most human -relevant tissue models, this work empowers researchers to overcome limitations of two-dimensional cultures and conduct advanced disease modeling research. English Korean Society for Stem Cell Research Guidelines for Manufacturing and Application of Organoids: Brain Article 10.15283/ijsc24056 1 International Journal of Stem Cells, v.17, no.2, pp.158 - 181 International Journal of Stem Cells 17 2 158 181 Y scie 001230111400001 Cell & Tissue Engineering Cell Biology Cell Biology Article; Early Access PLURIPOTENT STEM-CELLS CEREBRAL ORGANOIDS DIFFERENTIATION GENERATION TISSUES Organoid Brain organoid Neural organoid Guideline