Jang, Yerim Roh, Soonjong Cho, Younghak Jung, Youngmee Lee, Kangwon Choi, Nakwon Yoo, Jin Seong, Hyejeong 2024-06-13T01:30:13Z 2024-06-13T01:30:13Z 2024-06-13 2024-10 2524-7921 https://pubs.kist.re.kr/handle/201004/150050 An advanced approach for functionalizing the surfaces of electrospun poly(l-lactide-co-epsilon-caprolactone) (PLCL) nanofibers for biomedical applications is presented here. Using initiated chemical vapor deposition (iCVD), a coating of the copolymer p(PFMA-co-DVB) containing poly(pentafluorophenyl methacrylate) (PFMA) and divinylbenzene (DVB) was applied to the PLCL nanofibers. This coating facilitated efficient immobilization of the biomolecules on the PLCL nanofiber surfaces, allowing precise adjustments to the polymer composition through modulation of the monomer flow rates. The resulting copolymer exhibited superior efficiency for immobilizing IgG, as confirmed by immunofluorescence intensity analysis. In vitro studies conducted with different neural cell types demonstrated that the laminin-coated iCVD-functionalized PLCL nanofibers maintained their inherent biocompatibility while significantly enhancing cell adhesion. By exploiting the elastic nature of the PLCL nanofibers, cell elongation could be successfully manipulated by controlling the nanofiber alignment, as demonstrated by scanning electron microscopy and quantification of the immunofluorescence image orientation. These findings highlight the potential of iCVD-modified PLCL nanofibers as versatile platforms for neural tissue engineering and various biomedical applications, allowing valuable biomaterial surface modifications for enhanced cellular interactions. English Springer Nature Facile Surface Functionalization of Electrospun Elastic Nanofibers Via Initiated Chemical Vapor Deposition for Enhanced Neural Cell Adhesion and Alignment Article 10.1007/s42765-024-00438-0 1 Advanced Fiber Materials, v.6, no.5, pp.1583 - 1595 Advanced Fiber Materials 6 5 1583 1595 N scie scopus 001237089400002 2-s2.0-85194969917 Materials Science, Multidisciplinary Materials Science, Textiles Materials Science Article PLCL IMMOBILIZATION SCAFFOLD PROTEIN PENTAFLUOROPHENYL ADSORPTION ICVD DIFFERENTIATION FABRICATION REACTIVITY Poly(l-lactide-co-epsilon-caprolactone) Post-surface modification Neural cells Electrospun nanofiber Initiated chemical vapor deposition