Lee, Jeongyoon Kwak, Damhyeon Lee, Gwang Ung Kim, Chan Yeong Kim, Jihoon Park, Sang Hyun Choi, Jee Hyun Lee, Sung Q. Choe, Han Kyoung 2024-06-20T05:00:19Z 2024-06-20T05:00:19Z 2024-06-20 2024-05 https://pubs.kist.re.kr/handle/201004/150102 Although mice are social, multiple animals' neural activities are rarely explored. To characterise the neural activities during multi-brain interaction, we simultaneously recorded local field potentials (LFP) in the prefrontal cortex of four mice. The social context and locomotive states predominately modulated the entire LFP structure. The power of lower frequency bands-delta to alpha-were correlated with each other and anti-correlated with gamma power. The high-to-low-power ratio (HLR) provided a useful measure to understand LFP changes along the change of behavioural and locomotive states. The HLR during huddled conditions was lower than that during non-huddled conditions, dividing the social context into two. Multi-brain analyses of HLR indicated that the mice in the group displayed high cross-correlation. The mice in the group often showed unilateral precedence of HLR by Granger causality analysis, possibly comprising a hierarchical social structure. Overall, this study shows the importance of the social environment in brain dynamics and emphasises the simultaneous multi-brain recordings in social neuroscience. English Nature Publishing Group Social context modulates multibrain broadband dynamics and functional brain-to-brain coupling in the group of mice Article 10.1038/s41598-024-62070-7 1 Scientific Reports, v.14, no.1 Scientific Reports 14 1 Y scie scopus 001228252900023 2-s2.0-85193698728 Multidisciplinary Sciences Science & Technology - Other Topics Article HYPOTHYROIDISM ASSOCIATION ADULTS KLOTHO