Um, Seung-Hoon Lee, Jaehong Chae, Minseong Paternoster, Carlo Copes, Francesco Chevallier, Pascale Lee, Dong-Ho Hwang, Suk-Won Kim, Yu-Chan Han, Hyung-Seop Lee, Kang-Sik Mantovani, Diego Jeon, Hojeong 2024-07-11T06:00:57Z 2024-07-11T06:00:57Z 2024-07-11 2024-10 2192-2640 https://pubs.kist.re.kr/handle/201004/150212 Polyetheretherketone (PEEK), a bioinert polymer known for its mechanical properties similar to bone, is capable of averting stress shielding. Due to these attributes, it finds applications in diverse fields like orthopedics, encompassing cervical disc replacement for the neck and spine, along with dentistry and plastic surgery. However, due to insufficient bonding with bone, various methods such as hydroxyapatite (HA) coating on the surface are attempted. Nonetheless, the interface between the polymer and ceramic, two different materials, tended to delaminate after transplantation, posing challenges in preventing implant escape or dislodgement. This research delves into the laser-driven hydroxyapatite penetration-synthesis technique. Differing from conventional coating methods that bond layers of dissimilar materials like HA and PEEK, this technology focuses on synthesizing and infiltrating ionized HA within the PEEK substrate resulting in an interface-free HA-PEEK surface. Conversely, HA-PEEK with this technology applied achieves complete, gap-free direct bone-implant integration. Our research involved the analysis of various aspects. By means of these, we quantitatively assesed the enhanced bone bonding characteristics of HA-PEEK surfaces treated with this approach and offered and explanation for the mechanism responsible for direct bone integration. The ceramic-polymer fusion by laser driven penetration-synthesis of ionized precursor solution within the polymer matrix is presented. Differing from adhesion or blending, this approach creates a ceramic-polymer mutual fusion devoid of interfaces. Polyetheretherketone, a medical polymer treated with this technique, has achieved durability, biocompatibility, and direct tissue integration surpassing the required standards. image English Wiley-Blackwell Biomedical Device Surface Treatment by Laser-Driven Hydroxyapatite Penetration-Synthesis Technique for Gapless PEEK-to-Bone Integration Article 10.1002/adhm.202401260 1 Advanced Healthcare Materials, v.13, no.26 Advanced Healthcare Materials 13 26 N scie scopus 001259652500001 Engineering, Biomedical Nanoscience & Nanotechnology Materials Science, Biomaterials Engineering Science & Technology - Other Topics Materials Science Article POLYETHERETHERKETONE PEEK STATE OSSEOINTEGRATION COMPOSITES ATTACHMENT PROTEINS COATINGS KETONE) CELLS hydroxyapatite nanosecond laser polyetheretherketone surface treatment direct bone integration