Nam, Min-Ho Na, Heesu Justin Lee C. Yun M. 2024-07-15T02:30:10Z 2024-07-15T02:30:10Z 2024-07-12 2024-06 1869-3474 https://pubs.kist.re.kr/handle/201004/150234 Astrocytes primarily maintain physiological brain homeostasis. However, under various pathological conditions, they can undergo morphological, transcriptomic, and functional transformations, collectively referred to as reactive astrogliosis. Recent studies have accumulated lines of evidence that reactive astrogliosis plays a crucial role in the pathology of Alzheimer’s disease (AD). In particular, monoamine oxidase B, a mitochondrial enzyme mainly expressed in astrocytes, significantly contributes to neuronal dysfunction and neurodegeneration in AD brains. Moreover, it has been reported that reactive astrogliosis precedes other pathological hallmarks such as amyloid-beta plaque deposition and tau tangle formation in AD. Due to the early onset and profound impact of reactive astrocytes on pathology, there have been extensive efforts in the past decade to visualize these cells in the brains of AD patients using positron emission tomography (PET) imaging. In this review, we summarize the recent studies regarding the essential pathological importance of reactive astrocytes in AD and their application as a target for PET imaging. English 대한핵의학회 A Key Mediator and Imaging Target in Alzheimer’s Disease: Unlocking the Role of Reactive Astrogliosis Through MAOB Article 10.1007/s13139-023-00837-y 1 Nuclear Medicine and Molecular Imaging, v.58, no.4, pp.177 - 184 Nuclear Medicine and Molecular Imaging 58 4 177 184 N scopus kci ART003107666 2-s2.0-85182488134