Kim, Jushin Choi, Ji Won Kim, Hyeon Jeong Kim, Byungeun Kim, Yoowon Lee, Elijah Hwejin Kim, Rium Kim, Jaehwan Park, Jiwoo Jeong, Yeeun Park, Jong-Hyun Park, Ki Duk 2024-07-18T08:00:49Z 2024-07-18T08:00:49Z 2024-07-18 2024-09 1860-7179 https://pubs.kist.re.kr/handle/201004/150279 Neuroinflammation is an inflammatory immune response that arises in the central nervous system. It is one of the primary causes of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Phloroglucinol (PG) is a natural product contained in extracts of plant, algae and microbe and has been reported to have antioxidant and anti-inflammatory properties. In this study, we synthesized PG derivatives to enhance antioxidant and anti-inflammatory activity. Among PG derivatives, 6 a suppressed pro-oxidative and inflammatory molecule nitric oxide (NO) production more effectively than PG. Moreover, 6 a dose-dependently reduced the expression of proinflammatory cytokines such as IL-6, IL-1 beta, TNF-alpha, and NO producing enzyme iNOS in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. Additionally, we confirmed that 6 a alleviated cognitive impairment and glial activation in mouse model of LPS-induced neuroinflammation. These findings suggest that novel PG derivative, 6 a, is a potential treatment for neurodegenerative diseases. We designed and synthesized various derivatives to enhance the efficacy of phloroglucinol, which has been reported to have anti-inflammatory and antioxidant properties. Among them, compound 6 a significantly suppressed inflammatory responses in stimulated BV-2 microglial cells and effectively attenuated cognitive impairment and glial activation in LPS-induced neuroinflammation mouse model. image English Wiley - V C H Verlag GmbbH & Co. Phloroglucinol Derivatives Exert Anti-Inflammatory Effects and Attenuate Cognitive Impairment in LPS-Induced Mouse Model Article 10.1002/cmdc.202400056 1 ChemMedChem, v.19, no.17 ChemMedChem 19 17 Y scie scopus 001261390400001 2-s2.0-85197392505 Chemistry, Medicinal Pharmacology & Pharmacy Pharmacology & Pharmacy Article OXIDATIVE STRESS NITRIC-OXIDE BRAIN-INJURY ACTIVATION NEUROINFLAMMATION NEURODEGENERATION INFLAMMATION DISCOVERY TRIGGERS AGENTS Neurodegenerative disease Cognitive impairment Phloroglucinol Antioxidant Anti-inflammation