Hwang, Seongbeen Jung, Jinyoung Moon, Hyunoh Ko, Dai Sik Kim, Hyun-Woo Yoon, Jung-Pil Kim, Won Kyu Seol, Aeran Kim, Kihun Kim, Yun Hak 2024-07-26T05:30:21Z 2024-07-26T05:30:21Z 2024-07-25 2024-09 1876-2018 https://pubs.kist.re.kr/handle/201004/150301 Background: The escalating utilization of assisted reproductive technology (ART) in response to global infertility rates has spurred research into its complications. Short-term and long-term outcomes have been extensively studied, particularly the neurological concerns surrounding attention-deficit/hyperactivity disorder (ADHD) among ART-conceived children. This study aims investigate the association between ART and ADHD. Methods: Medline, Embase, Scopus, and Web of Science databases were searched through April 4, 2023. Cohort, case-control, and cross-sectional studies were eligible for inclusion. primary summary measures included the unadjusted relative risk (RR) and adjusted hazard ratio (HR) with 95 % confidence intervals. Both fixed-effects and random-effects models were utilized for meta-analysis data pooling to determine the overall effect size. The onset of ADHD in children conceived through ART compared to those conceived naturally. Results: The systematic search yielded 8 studies with 10,176,148 individuals included in the meta-analysis. The meta-analysis revealed a pooled RR of 0.93 (0.68-1.26) for cohort studies and a pooled RR of 0.97 (0.41-2.29) for cross-sectional studies, along with a pooled HR of 1.08 (1.03-1.13) for ADHD in the ART group compared to the non-ART group. Conclusion: While this study identifies some potential association between ART and ADHD, the limited effect size and inherent heterogeneity underscore the need for cautious interpretation. English Elsevier BV The impact of assisted reproductive technologies on ADHD: A systematic review and meta-analysis Article 10.1016/j.ajp.2024.104125 1 Asian Journal of Psychiatry, v.99 Asian Journal of Psychiatry 99 N scie scopus 001267100700001 2-s2.0-85197500103 Psychiatry Psychiatry Review ATTENTION-DEFICIT/HYPERACTIVITY DISORDER CHILDREN BORN IN-VITRO NORDIC REGISTER BIRTH WEIGHT COHORT RISK in vitro fertilization intra-cytoplasmic sperm injection assisted reproductive technology attention-deficit/hyperactivity disorder systematic review meta-analysis