Kim, Kyung Ho Kwak, Jisung Seo, Sung Eun Ha, Siyoung Kim, Gyeong-Ji Lee, Sangwoo Sim, Sang Jun Lee, Yeon Kyung Tran, Na Ly Oh, Seung Ja Kim, Woo-Keun Song, Hyun Seok Kwon, Oh Seok 2024-08-16T02:00:18Z 2024-08-16T02:00:18Z 2024-08-16 2024-09 0304-3894 https://pubs.kist.re.kr/handle/201004/150429 Although biocides are important materials in modern society and help protect human health and the environment, increasing exposure to combined biocides can cause severe side effects in the human body, such as lung fibrosis. In this study, we developed a receptonics system to screen for biocides in combined household chemical products based on biocides. The system contains transient receptor potential ankyrin 1 (TRPA1) nanovesicles (NVs) to sense biocides based on pain receptors and a side-gated field-effect transistor (SGFET) using a single- layer graphene (SLG) micropattern channel. The binding affinities between the TRPA1 receptor and the various biocides were estimated by performing biosimulation and using a calcium ion (Ca2+) 2 + ) assay, and the sensitivity of the system was compared with that of TRPA1 NV receptonics systems. Based on the results of the TRPA1 NV receptonics system, the antagonistic and potentiation effects of combined biocides and household chemical products depended on the concentration. Finally, the TRPA1 NV receptonics system was applied to screen for biocides in real products, and its performance was successful. Based on these results, the TRPA1 NV receptonics system can be utilized to perform risk evaluations and identify biocides in a simple and rapid manner. English Elsevier BV TRPA1 nanovesicle-conjugated receptonics for rapid biocide screening Article 10.1016/j.jhazmat.2024.135282 1 Journal of Hazardous Materials, v.477 Journal of Hazardous Materials 477 N scie scopus 001285948000001 2-s2.0-85199951600 Engineering, Environmental Environmental Sciences Engineering Environmental Sciences & Ecology Article FIELD-EFFECT TRANSISTOR CHANNELS CANCER NOSE Receptonics Bioelectronics Biocide screening TRPA1 AOP Real-time monitoring