Le, Tam Thi Kim, Jonghwan Kang, Tae Kyeom Lee, Wook-Bin Kim, Myungsuk Kim, Chung Sub Jung, Sang Hoon 2024-08-16T02:00:29Z 2024-08-16T02:00:29Z 2024-08-16 2024-08 https://pubs.kist.re.kr/handle/201004/150431 Myristica fragrans Houtt. is rich in lignans, neolignans, and diarylnonanoids, with well-documented anti-inflammatory properties. However, there is limited research on the conjugated forms of diarylnonanoids, neolignans, monoterpenes, and others and their anti-inflammatory effects. Our study isolated 33 new compounds (2-7, 9-22, and 41-52), including two neolignans, alongside various neolignan-diarylnonanoid, propenylbenzene-diarylnonanoid, 2,3-dimethylbutane-type lignan-diarylnonanoid, and monoterpene-diarylnonanoid conjugates, along with previously reported compounds (1, 8, and 23-40). Their chemical structures were determined via spectroscopic analyses. Compounds 2, 4, 9, 11, 12, 14, 17, and 18 exhibited potent inhibition of NF-kappa B/AP1 and IRF signaling induced by TLR agonists. Notably, stereoisomers showed distinct behavior, while 10R,11R-isomers induced cytotoxicity, and 10S,11R-isomers produced contrasting effects, especially within group-I compounds. English ACS Publications Neolignans and Diarylnonanoid Derivatives with Anti-inflammatory Activity from Myristica fragrans Houtt. Seeds Article 10.1021/acsomega.4c05649 1 ACS Omega, v.9, no.32, pp.35170 - 35181 ACS Omega 9 32 35170 35181 Y scie scopus 001282069900001 2-s2.0-85199958633 Chemistry, Multidisciplinary Chemistry Article ESSENTIAL OIL IN-VITRO NUTMEG CONSTITUENTS MACE LIPOPOLYSACCHARIDE ACYLPHENOLS INHIBITION ACID ARIL