Hwang, Hee Jae Choi, Yunseok Kim, Seongchan Lee, Sun Hee Choi, Soon Jin Kwon, Hee-Young Kwon, Daehyeok Park, Soyeon Lee, Hyojin Ok, Myoung-Ryul Kim, Yu-Chan Park, Bo-In Han, Hyung-Seop 2024-09-19T01:30:05Z 2024-09-19T01:30:05Z 2024-09-19 2024-12 2211-2855 https://pubs.kist.re.kr/handle/201004/150613 Wound healing involves a complex series of coordinated events throughout the inflammatory, proliferative, and maturation phases of tissue repair. Current treatment modalities lack a device catering to all wound healing stages for tissue recovery, angiogenesis and epithelialization. Herein, we developed an integrated wound healing system with multiple functions of self-electrical stimulation (ES), reactive oxygen species (ROS) regulation, and bioactive metal-releasing patch (ERMP) to address all wound healing stages including hemostasis, inflammation, proliferation, and remodeling. The multiple functions of ERMP are ES, generated by the movement of the mice, for tissue regeneration, magnesium (Mg) ion release via iontophoresis triggered by ES for pro-angiogenic effects, and simultaneous regulation of ROS. This system employs self-generating ES utilizing the movements of the individuals to trigger triboelectric nanogenerators (TENGs), which consequently transfer ES through Mg microneedles while effectively delivering enhanced Mg ions with an iontophoresis via ES to the wound site. Specially, Prussian blue (PB) was utilized to not only enhance output performance on TENG as charge trap, but also regulate excessive ROS via modified PB with carbon-nitrogen vacancies in the wound site. The synergistic effects of ES, ROS regulation, and enhanced Mg ions releases led to a nine-fold recovery rates in wound healing compared to the control group in vivo tests. This approach addresses the inherent limitations of conventional wound healing methods and provides a viable treatment for various severe wound types. English Elsevier BV Synergistic integration of electrical stimulation, reactive oxygen species regulation, and pro-angiogenic for accelerated wound healing Article 10.1016/j.nanoen.2024.110200 1 Nano Energy, v.131 Nano Energy 131 Y scie scopus 001308040100001 2-s2.0-85202947610 Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Chemistry Science & Technology - Other Topics Materials Science Physics Article MAGNESIUM MODEL Integrated wound healing system Self-electrical stimulation Reactive oxygen species regulation Magnesium microneedles Prussian blue