Noh, Dahye Lee, Hokyung Lee, Sangmin Sun, In-Cheol Yoon, Hong Yeol 2024-10-21T04:30:13Z 2024-10-21T04:30:13Z 2024-10-21 2024-10 1226-4601 https://pubs.kist.re.kr/handle/201004/150828 The recent discovery of cuproptosis, a novel copper-ion-induced cell death pathway, has suggested the novel therapeutic potential for treating heterogeneous and drug-resistant cancers. Currently, copper ionophore-based therapeutics have been designed to treat cancers, utilizing copper ions as a strategic tool to impede tumor proliferation and promote cellular demise. However, limitations of copper ionophore-based therapies include nontargeted delivery of copper ions, low tumor accumulation, and short half-life. Strategies to enhance specificity involve targeting intracellular cuproptosis mechanisms using nanotechnology-based drugs. Additionally, the importance of exploring combination therapies cannot be overstated, as they are a key strategy in improving the efficacy of cancer treatments. Recent studies have reported the anticancer effects of nanomedicines that can induce cuproptosis of cancer both in vitro and in vivo. These cuproptosis-targeted nanomedicines could improve delivery efficiency with the pharmacokinetic properties of copper ion, resulting in increasing cuproptosis-based anticancer effects. This review will summarize the intricate nexus between copper ion and carcinogenesis, examining the pivotal roles of copper homeostasis and its dysregulation in cancer progression and fatality. Furthermore, we will introduce the latest advances in cuproptosis-targeted nanomedicines for cancer treatment. Finally, the challenges in cuproptosis-based nanomedicines will be discussed for future development directions. English The Korean Society for Biomaterials | BioMed Central Copper-Based Nanomedicines for Cuproptosis-Mediated Effective Cancer Treatment Article 10.34133/bmr.0094 1 Biomaterials Research, v.28 Biomaterials Research 28 Y scie scopus kci 001337975600001 Engineering, Biomedical Materials Science, Biomaterials Engineering Materials Science Review INTUSSUSCEPTIVE MICROVASCULAR GROWTH CYSTATHIONINE-BETA-SYNTHASE LYSYL OXIDASE CELL-DEATH HYDROGEN-SULFIDE OXIDATIVE STRESS DRUG ANGIOGENESIS TRANSPORT BINDING