Hwang, Soonjae Jo, Minjeong Hong, Ju-Eun Kim, Woo-Seung Kang, Da-Hye Yoo, Sang-Hyeon Kang, Kyungsu Rhee, Ki-Jong 2024-10-26T07:00:46Z 2024-10-26T07:00:46Z 2024-10-25 2024-09 https://pubs.kist.re.kr/handle/201004/150873 The human colonic commensal enterotoxigenic Bacteroides fragilis (ETBF) is associated with chronic colitis and colon cancer. ETBF colonization induces colitis via the Bacteroides fragilis toxin (BFT). BFT secreted by ETBF cause colon inflammation via E-cadherin cleavage/NF-kappa B signaling. ETBF promotes colon tumorigenesis via interleukin 17A (IL-17A)/CXCL-dependent inflammation, but its bioactive therapeutics in ETBF-promoted tumorigenesis remain unexplored. In the current study, we investigated the caffeic acid phenethyl ester (CAPE) in the murine model of ETBF colitis and tumorigenesis. In this study, we observed that CAPE treatment mitigated inflammation induced by ETBF in mice. Additionally, our findings indicate that CAPE treatment offers protective effects against ETBF-enhanced colon tumorigenesis in a mouse model of colitis-associated colon cancer induced by azoxymethane (AOM) and dextran sulfate sodium. Notably, the decrease in colon tumorigenesis following CAPE administration correlates with a reduction in the expression of IL-17A and CXCL1 in the gastrointestinal tract. The molecular mechanism for CAPE-induced protection against ETBF-mediated tumorigenesis is mediated by IL-17A/CXCL1, and by NF-kappa B activity in intestinal epithelial cells. Our findings indicate that CAPE may serve as a preventive agent against the development of ETBF-induced colitis and colorectal cancer (CRC). English Multidisciplinary Digital Publishing Institute (MDPI) Caffeic Acid Phenethyl Ester Administration Reduces Enterotoxigenic Bacteroides fragilis-Induced Colitis and Tumorigenesis Article 10.3390/toxins16090403 1 Toxins, v.16, no.9 Toxins 16 9 Y scie scopus 001326152200001 2-s2.0-85205151743 Food Science & Technology Toxicology Food Science & Technology Toxicology Article FACTOR-KAPPA-B NUCLEAR-FACTOR COLON TUMORIGENESIS COLORECTAL-CANCER ACTIVATION CELLS GROWTH CAPE SUPPLEMENTATION INFLAMMATION caffeic acid phenethyl ester ETBF BFT colitis tumorigenesis