Lee, Hyeon-Jeong Seo, Yoondam Kang, In Seon Hwang, Ji In Lee, Gahyeon Min, Ho phil 2024-11-04T12:00:20Z 2024-11-04T12:00:20Z 2024-10-28 2024-06-27 https://pubs.kist.re.kr/handle/201004/150945 The health benefits of physical activity are widely acknowledged and impact various organ systems as promoting overall resilience and longevity. Following the research of discovering signaling molecules that are released in response to exercise from various organs such as skeletal muscle, heart, neurons, and adipose tissue exerting their effects through endocrine, paracrine, or autocrine pathways, numerous functional molecules caused by physical activity have been identified. However, controversial issues persist inconsistencies between responses to acute and chronic exercise, and differences observed between human and animal exercise models. Therefore, to understand the precise molecular mechanisms responsible for these benefits, and provide robust ground for future advancements in exercise biomarker research, well-structured biomarker profiling analysis with controlled sampling methods from elite athletes is essential. In this study, we identified various proteomic biomarkers from elite athletes and the suggested proteins showed promising relationships with enhancing cardiovascular, metabolic immune, and neurological health, suggesting potential applications in treating cardiovascular disease, type 2 diabetes, obesity, and promoting healthy aging. In addition, this study emphasizes the significance of using a meticulous sampling strategy to yield precise findings on functional molecules triggered by exercise. English 한국단백체학회(KHUPO) Proteomic biomarker profiling for discovering muscle, bone, and fat cross talk from elite athletes Conference 2 제22차 한국단백체학회 연례 학술대회(KHUPO 2024) 제22차 한국단백체학회 연례 학술대회(KHUPO 2024) KO 여수 엑스포 컨벤션 센터 2024-06-25 제22차 한국단백체학회 연례 학술대회(KHUPO 2024)