Sohn, Eun-Hwa Kim, Su-Nam Lee, Sung-Ryul 2024-11-30T06:30:33Z 2024-11-30T06:30:33Z 2024-11-30 2024-10 https://pubs.kist.re.kr/handle/201004/151225 Melatonin (5-methoxy-N-acetyltryptamine) is an indoleamine compound that plays a critical role in the regulation of circadian rhythms. While melatonin is primarily synthesized from the amino acid tryptophan in the pineal gland of the brain, it can also be produced locally in various tissues, such as the skin and intestines. Melatonin's effects in target tissues can be mediated through receptor-dependent mechanisms. Additionally, melatonin exerts various actions via receptor-independent pathways. In biological systems, melatonin and its endogenous metabolites often produce similar effects. While injuries are common in daily life, promoting optimal wound healing is essential for patient well-being and healthcare outcomes. Beyond regulating circadian rhythms as a neuroendocrine hormone, melatonin may enhance wound healing through (1) potent antioxidant properties, (2) anti-inflammatory actions, (3) infection control, (4) regulation of vascular reactivity and angiogenesis, (5) analgesic (pain-relieving) effects, and (6) anti-pruritic (anti-itch) effects. This review aims to provide a comprehensive overview of scientific studies that demonstrate melatonin's potential roles in supporting effective wound healing. English MDPI AG Melatonin's Impact on Wound Healing Article 10.3390/antiox13101197 1 Antioxidants, v.13, no.10 Antioxidants 13 10 Y scie scopus 001343051700001 2-s2.0-85207685537 Biochemistry & Molecular Biology Chemistry, Medicinal Food Science & Technology Biochemistry & Molecular Biology Pharmacology & Pharmacy Food Science & Technology Review OXIDATIVE STRESS GENE-EXPRESSION RADIATION DERMATITIS CIRCADIAN-RHYTHMS VIRAL-INFECTIONS REACTIVE OXYGEN ANTIOXIDANT RAT PREVENTION BINDING antioxidant inflammation injury melatonin oxidative stress pineal gland wound healing