Park, Minji Lee, Hyun Jang, Yerim Kim, Min Ji Cho, Younghak Liu, Sophie S. Lee, Jungeun Shim, Surim Jung, Hyun-Do Seong, Hyejeong Yang, Kisuk 2025-01-07T02:30:34Z 2025-01-07T02:30:34Z 2024-12-30 2024-12 1944-8244 https://pubs.kist.re.kr/handle/201004/151474 Treating type 1 diabetes (T1D) through beta-cell macroencapsulation is a promising long-term solution, but it faces challenges such as immune-mediated fibrosis on the capsule surface, which impairs cell functionality and compromises longevity and effectiveness. This study presents an approach for including an anti-inflammatory molecule on the macroencapsulation device (MED) using initiated chemical vapor deposition for the surface modification of poly(tetrafluoroethylene) (PTFE) membranes. The surface-modified MEDs significantly reduced fibrosis, improved beta-cell viability and functionality, and promoted M2 macrophage polarization, which is associated with anti-inflammatory effects. This MED displayed improved glycemic control in a streptozotocin-induced diabetic mouse model for 45 days. The findings underscore the potential of surface-modified MEDs for improving T1D management by mitigating inflammation and enhancing the therapeutic efficacy of beta-cell encapsulation. English American Chemical Society Macroencapsulation Device with Anti-inflammatory Membrane Modification Enhances Long-Term Viability and Function of Transplanted β Cells Article 10.1021/acsami.4c14057 1 ACS Applied Materials & Interfaces, v.16, no.51, pp.70218 - 70230 ACS Applied Materials & Interfaces 16 51 70218 70230 N scie scopus 001375999700001 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article INSULIN DELIVERY MOUSE MODEL ENCAPSULATION DIFFERENTIATION PANCREATIC-ISLETS type 1 diabetes (T1D) beta cell macroencapsulation initiatedchemical vapor deposition (iCVD) functionalizedmembrane anti-inflammatory molecule macrophagepolarization