Song, Aeran Kim, Min Jung Yi, Dong-Joon Kwon, Soyeong Kim, Dong-Wook Kim, Seunghwan Bae, Jee-Hwan Park, Soohyung Rim, You Seung Jeong, Kwang-Sik Chung, Kwun-Bum 2025-04-25T05:30:31Z 2025-04-25T05:30:31Z 2025-04-25 2024-11 https://pubs.kist.re.kr/handle/201004/152295 In this study, the sensitivity of electrolyte-gated field-effect transistor-based glucose sensors using oxide semiconductor materials was controlled via electronegativity modulation. By controlling the enzymatic reaction between glucose and glucose oxidase, which is affected by the surface potential, the sensitivity of the glucose sensor can be effectively adjusted. To evaluate the sensitivity characteristics of the glucose sensor according to electronegativity control, devices were fabricated based on InO through Ga and Zn doping. The results confirmed that the specific sensitivity range could be adjusted by increasing the electronegativity. In addition, density functional theory calculations, confirmed that the attachment energy of the surface-functionalized material and the enzyme binding energy in the surface-functionalized thin film can be modulated depending on the electronegativity difference. The dissociation constant was controlled in both directions by doping with metal cations with larger(Ga, 1.81) or smaller(Zn, 1.65) electronegativities in InO(In, 1.78). We expect that this study will provide a simple method for the gradual and bidirectional control of the glucose sensitivity region. English Nature Publishing Group Control of sensitivity in metal oxide electrolyte gated field-effect transistor-based glucose sensor by electronegativity modulation Article 10.1038/s41598-024-76885-x 1 Scientific Reports, v.14, no.1 Scientific Reports 14 1 Y scie scopus 001457881200020 2-s2.0-85209480944 Multidisciplinary Sciences Science & Technology - Other Topics Article IMMOBILIZATION COMPLICATIONS BIOSENSORS NANOTUBES InO InZnO InGaO Density functional theory (DFT) Glucose sensor Electronegativity