Park, Young-Geun Kim, Sumin Min, Sungjin Kim, Enji Kim, Dayeon Cho, Yo Han Kim, Suran Joo, Hyebin Jeong, Inhea Lim, Jung Ah Lee, Sangmin Cho, Seung-Woo Park, Jang-Ung 2025-04-25T07:31:30Z 2025-04-25T07:31:30Z 2025-04-25 2025-04 1530-6984 https://pubs.kist.re.kr/handle/201004/152336 Continuous monitoring of physiological activities within the internal regions of three-dimensional (3D) organoids holds significant promise for advancing organoid-based research. However, conventional methods are constrained to capturing signals from the peripheral surfaces of organoids, limiting insights into internal dynamics. Here, we present a soft 3D bioelectrode platform for continuous intraorganoid signal monitoring. These bioelectrodes, formed via 3D printing of liquid metal, are designed with customizable geometric parameters, including height and diameter, to adapt to various organoid structures. The tissue-comparable softness of the electrodes minimizes damage to cardiac organoids, ensuring a stable interface for reliable signal recording even under dynamic deformations caused by rhythmic contractions or displacements in aqueous environments. The array configuration enables simultaneous electrocardiogram (ECG) recordings from 32 organoids. Demonstrating real-time monitoring of drug-induced ECG responses, this scalable platform highlights its potential for high-throughput drug screening. English American Chemical Society Soft 3D Bioelectrodes for Intraorganoid Signal Monitoring in Cardiac Models Article 10.1021/acs.nanolett.5c00069 1 Nano Letters, v.25, no.16, pp.6481 - 6490 Nano Letters 25 16 6481 6490 N scie scopus 001462755300001 2-s2.0-105002678873 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article LONG-QT SYNDROME ARRAY Liquid metals Bioelectrodes 3D printing Cardiac organoids