Lee, Su Eon
Lee, Hanna
Kim, Jang Hwan
Park, Sungwook
Oh, Young Taek
Choi, Hayoung
Kim, JeongMin
Jo, HyeJun
Park, Jun Hyun
Jin, Ho Jun
Lee, Kwan Hyi
Han, Seung Ho
Kim, Hojun
Oh, Jun Kyun
Kim, Bong Hoon
2025-05-27T02:00:12Z
2025-05-27T02:00:12Z
2025-05-27
2025-08
2192-2640
https://pubs.kist.re.kr/handle/201004/152519
The surface properties of the epidermis are crucial in pathogen adhesion and proliferation. Moreover, damage to the epidermis caused by various physical and chemical attacks provides a favorable environment for pathogen penetration and proliferation through the exposed internal living tissue. Surface modification of the epidermis to impart anti-biofouling properties can provide effective protection against infections. In this study, a facile method of imparting multiple anti-biofouling functions by directly modifying the epidermal surface of an organism using dopamine, which is a mussel-inspired substance, is introduced. Biocompatible polydopamine (PDA) is uniformly applied to organic surfaces with diverse morphological features and surface energies, indicating its versatility. In addition, the reliability of epidermal modification with PDA is confirmed via the PDA-induced prevention of chronic changes in the impedance of the epidermis. Critically, the PDA-modified epidermis exhibited various anti-biofouling functions, including antibacterial and anti-adsorption properties against bacteria and cellular/noncellular microorganisms, respectively. Improved antibacterial properties are successfully realized via integration with tobramycin, which is a representative antibiotic. Direct surface modification using PDA offers an innovative approach to safeguard biological surfaces, particularly the human epidermis, against various pathogens, with potential for application in medical patches and skin-attached devices.
English
Wiley-Blackwell
Direct Surface Modification of the Epidermis Using MusselInspired Polydopamine with Multiple AntiBiofouling Functions
Article
10.1002/adhm.202500597
1
Advanced Healthcare Materials, v.14, no.20
Advanced Healthcare Materials
14
20
Y
scie
scopus
001493597100001
Engineering, Biomedical
Nanoscience & Nanotechnology
Materials Science, Biomaterials
Engineering
Science & Technology - Other Topics
Materials Science
Article
ANTIMICROBIAL ACTIVITY
CHEMISTRY
GRAPHENE
HUMAN SKIN
antibacterial
antiviral
direct coating
polydopamine coatings
surface modifications