Kim, Jisun Bong, Ki Wan Cho, Jung-Kyo Song, Soo-Chang 2025-06-26T09:00:06Z 2025-06-26T09:00:06Z 2025-06-23 2025-06 2050-750X https://pubs.kist.re.kr/handle/201004/152695 In modern society, the need for diabetic wound healing is increasing due to the increase in the number of diabetic patients. In particular, chronic inflammation is a major problem in diabetic wounds due to excessive accumulation of reactive oxygen species (ROS). Therefore, it is essential to remove ROS and promote angiogenesis for effective diabetic wound healing. In this study, we developed a thermo-responsive poly(organophosphazene) hydrogel system (TSP-TP) designed to deliver antioxidants and growth factors for a long period of time. The TSP-TP hydrogel stably loads and continuously releases tannic acid (TA) and platelet-derived growth factor (PDGF) through various physical interactions. Effective ROS scavenging induced macrophage polarization and alleviated chronic inflammation, while the sustained release of PDGF promoted angiogenesis, ultimately maximizing wound healing efficacy in a diabetic mouse model. Based on these results, the proposed TSP-TP hydrogel demonstrates synergistic effects through sustained delivery of antioxidants and growth factors, demonstrating a promising system with high applicability in diabetic wound treatment. English Royal Society of Chemistry Thermo-responsive hydrogel via sustained Co-delivery of TA and PDGF to modulate the diabetic microenvironment and accelerate diabetic wound healing Article 10.1039/d5tb00563a 1 Journal of Materials Chemistry B, v.13, no.24, pp.7090 - 7105 Journal of Materials Chemistry B 13 24 7090 7105 Y scie scopus 001507045100001 2-s2.0-105005808149 Materials Science, Biomaterials Materials Science Article DRUG-RELEASE REGENERATION INFLAMMATION ANTIOXIDANT MACROPHAGES SCAFFOLDS BOND TANNIC-ACID GROWTH-FACTOR