Tewari, Devesh Choudhary, Neeraj Tiwari, Himani Chetna, Tewari Rawat, Kundan Singh Rana, Sravendra Jung, Yong Chae Sahoo, Nanda Gopal 2025-07-08T08:30:08Z 2025-07-08T08:30:08Z 2025-07-04 2025-12 2772-9516 https://pubs.kist.re.kr/handle/201004/152732 Cancer therapeutics require a deep understanding of molecular mechanisms and novel drug delivery approaches. Click chemistry, a powerful tool for the rapid and efficient formation of covalent bonds emerged as a cherished technique for designing and synthesizing molecular probes. The present paper explores the potential of click chemistry with graphene modifications for possible cancer therapeutics for the first time. Diverse click reactions is discussed that are employed in the synthesis of molecular probes using graphene as a platform for drug delivery and imaging. The paper highlights recent advances in the application of click chemistry and graphene modifications for the design of targeted therapeutics that selectively inhibit cancer cell growth and survival. A possible approach of targeting various cancer signaling pathways based on graphene-coupled drug delivery techniques along with challenges and opportunities associated with the use of these molecular design strategies for the development of personalized cancer therapies is also discussed in detail. English ELSEVIER Integration of click chemistry and graphene driven molecular design: A mechanistic standpoint on targeted cancer therapeutics Article 10.1016/j.bioadv.2025.214399 1 Biomaterials Advances, v.177 Biomaterials Advances 177 N scie scopus 001529284600001 Materials Science, Biomaterials Materials Science Review FUNCTIONALIZED NANOGRAPHENE OXIDE ANTIGEN-PRESENTING CELLS ONE-POT SYNTHESIS IN-VITRO BIOLOGICAL EVALUATION POTENTIAL ANTICANCER DRUG-DELIVERY BREAST-CANCER QUANTUM DOTS CYTOTOXIC EVALUATION Bioorthogonal reactions Click chemistry cancer Drug delivery Graphene