Kim, Jin-Woo Dorjsembe, Banzragch Chang, Pahn-Shick Kim, Jin-Chul 2025-07-17T07:00:09Z 2025-07-17T07:00:09Z 2025-07-14 2025-10 1226-7708 https://pubs.kist.re.kr/handle/201004/152743 The combination of Curcuma longa extract and its active compounds, curcumin and bisdemethoxycurcumin, as photosensitizers with ultraviolet A (UVA) light has potential in alleviating psoriasis. This study evaluated their therapeutic effects on psoriasis-like lesions induced via imiquimod application in BALB/c mice. Treatments with Curcuma longa extract, curcumin, or bisdemethoxycurcumin combined with UVA (TUVA, CUVA, and BUVA, respectively) were administered. All treatments improved abnormal transepidermal water loss and subcutaneous hydration in the dorsal skin. TUVA and CUVA significantly reduced ear thickness and epithelial thickness in both the ear and dorsal skin. All treatments restored the expression of filaggrin, loricrin, and keratin 1, while downregulating interleukin-1 β, tumor necrosis factor-α, interferon-γ, and IL-23p19. These findings suggest that Curcuma longa extract, curcumin, or bisdemethoxycurcumin combined with UVA treatment may serve as potential alternatives to conventional antipsoriatic therapies such as psoralen plus ultraviolet A therapy. English 한국식품과학회 Effects of combined treatment with Curcuma longa extract, curcumin, or bisdemethoxycurcumin and UVA on imiquimod-induced psoriasis-like lesions in BALB/c mice Article 10.1007/s10068-025-01940-w 1 Food Science and Biotechnology, v.34, no.14, pp.3385 - 3394 Food Science and Biotechnology 34 14 3385 3394 N scie scopus kci ART003240785 001523846600001 Food Science & Technology Food Science & Technology Article PHOTOTHERAPY COMBINATION GROWTH PUVA Psoriasis Curcuma longa Curcumin Bisdemethoxycurcumin Photodynamic therapy