Lee, Yeon Kyung Kim, Taeyeon Chung, Seok Seo, Minah Song, Hyun Seok 2025-07-18T02:30:16Z 2025-07-18T02:30:16Z 2025-07-18 2025-09 1976-0280 https://pubs.kist.re.kr/handle/201004/152754 Over the past decades, terahertz technology has emerged as a novel biologic analytical tool. Terahertz waves are not radio waves or visible lights, but possess unique optical characteristics, which have a wide range of applications in molecular fingerprinting, structural bio-molecular analysis, and microenvironmental analysis at cellular and tissue levels. Because of its ability to probe fundamental interactions, terahertz technology allows for a deeper understanding of intricate biological systems through non-destructive detection methods. Despite significant advances, some challenges, such as limited spectral selectivity and significant absorption in aqueous environments, remain unaddressed. In this review, we aimed to highlight recent developments in terahertz spectroscopy, focusing on theoretical principles, applications in bio-sensing, and methodologies to overcome the limitations of biological applications. English 한국바이오칩학회 Frontier of Terahertz Spectroscopy: Unveiling Its Potential in Biochemical Applications Article 10.1007/s13206-025-00224-z 1 BioChip Journal, v.19, no.3, pp.424 - 443 BioChip Journal 19 3 424 443 N scie scopus kci ART003245654 001522693100001 Biochemical Research Methods Chemistry, Analytical Nanoscience & Nanotechnology Biochemistry & Molecular Biology Chemistry Science & Technology - Other Topics Review DER-WAALS INTERACTIONS DIELECTRIC-RELAXATION MOLECULAR-DYNAMICS LUNG-CANCER TIME PROTEIN DNA WATER TRANSITIONS ABSORPTION Terahertz spectroscopy Biosensor Bioimaging Biochemical analysis Dynamic analysis