Seo, Hyunseon Ko, Gwan-Jin Song, Sangmin Lee, Joong Hoon Seo, Youngmin Han, Sungkeun Eom, Chan-Hwi Kim, Hyewon Kim, Seongsoo Lee, Kang-Sik Kim, Yu-Chan Kim, Hojun Moon, Si-Eun Lee, Kyungwoo Ko, Seung Hwan Hwang, Suk-Won Jeon, Hojeong 2025-07-18T02:30:33Z 2025-07-18T02:30:33Z 2025-07-18 2025-09 https://pubs.kist.re.kr/handle/201004/152757 Stable and reliable operation of implantable electronics must ensure both high-quality electrical performance and chronic biocompatibility. Here, immune-stealth implantable electronics fabricated by multiphoton ablation lithography are introduced. The cell-repellent interface, consisting of micro-grooves and nano-islands, can be created by laser-assisted topography patterning on a thin film substrate. This patterned surface demonstrates a 20-fold increase in cell-repellent effectiveness against immune cells such as macrophages and fibroblasts due to disturbance of focal adhesion. Furthermore, the cell-repellent interface can also be patterned on the sub-micron electrode layer without compromising its electrical and electrochemical performance. When the electrocardiogram (ECG) sensor applying the cell-repellent interface is implanted into a rat subcutaneous tissue, inflammation and fibrotic reactions are effectively suppressed for 6 weeks. Consequently, stable ECG readings with clear PQRST waveforms are obtained in real-time for 4 weeks, suggesting its potential to enhance chronic biocompatibility of implantable electronics. English Wiley-VCH Verlag Topographical Patterning of Cell-Repellent Interfaces for Immune-Stealth Implantable Electronics via Multiphoton Ablation Lithography Article 10.1002/advs.202506482 1 Advanced Science, v.12, no.34 Advanced Science 12 34 Y scie scopus 001511535800001 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Article MACROPHAGES ACTIVATION NANOSCALE ADHESION FILMS GRAPHENE SYMMETRY implantable electronics laser processing multiscale topography topographical cue chronic biointerface