Kim, Taeyeon Lee, Yeon Kyung Roh, Yeeun Park, Jaehun Ryu, Yong-Sang Song, Hyun Seok Seo, Minah 2025-07-18T06:00:46Z 2025-07-18T06:00:46Z 2025-07-18 2025-10 0935-9648 https://pubs.kist.re.kr/handle/201004/152772 The rapid growth of nanotechnology and spectroscopic techniques has accelerated the development of biosensors with high sensitivity and selectivity. Nanoscale metasurfaces can potentially overcome the limitations of conventional optical methods, such as low responsivity and molecular specificity. One promising approach for analyzing subtle biochemical changes that occur in complex biological phenomena is to use terahertz metasurfaces. Here, the aim is to develop a dual-selective terahertz nanodisc metasurface that enabled precise monitoring of neurotransmitter dynamics in a biomimetic environment. Utilizing functionalized terahertz metasurfaces with nanodisc that mimic biosensory receptors, a biosensor selective for both molecular type and resonant frequency is developed. The sensing platform ensures significantly enhanced sensitivity and specificity by recognizing the intermolecular changes associated with serotonin-nanodisc binding and aqueous surrounding effects. The proposed biosensor can potentially provide an efficient tool for studying complex biochemical interactions, and find application in biomedical diagnostics and neuroscience research. English WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Dual-Selective Terahertz-Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations Article 10.1002/adma.202504858 1 Advanced Materials, v.37, no.41 Advanced Materials 37 41 Y scie scopus 001514475200001 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article 5-HT7 RECEPTOR SPECTROSCOPY biosensor GPCRs metasurface molecular dynamics nanodsic neurotransmitter sensing receptor-ligand interaction terahertz time-domain spectroscopy