Kim, Dong-Hwi Kim, Kyu-Sung Kim, Jae-Hyeong Lim, Kyu-Beom Jeon, Min-Tae Lee, Joong-Bok Park, Seung-Yong Song, Chang-Seon Lee, Sang-Won Lee, Dong-Hun Choi, Yang-Kyu Shin, Yeun-Kyung Kim, Do-Geun Choi, In-Soo 2025-07-29T06:30:26Z 2025-07-29T06:30:26Z 2025-07-28 2025-07 0146-6615 https://pubs.kist.re.kr/handle/201004/152866 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 causative agent, infects several species. Although COVID-19 was reported in some dogs, their roles in transmitting SARS-CoV-2 to other species remain unclear. We investigated the ability of COVID-19 infected dogs to transmit SARS-CoV-2 virus to hamsters and assessed associated pulmonary and neuropathological changes in hamsters. SARS-CoV-2-negative hamsters were placed in close proximity to infected dogs, and viral infection in hamsters was confirmed by infection-associated histopathological changes. SARS-CoV-2 exposure led to notable neurological effects in hamsters, including blood-brain barrier damage, activated immune response, and neurodegenerative changes. This study is the first one to confirm that dogs can transmit SARS-CoV-2 to other species and demonstrates that cross-species viral transmission can contribute to central nervous system pathology and promote neurodegenerative processes. These findings underscore the importance of further investigating dog-to-other species transmission pathways and early-stage neuropathological impacts of SARS-CoV-2 infection. English John Wiley & Sons Inc. Cross-Species Transmission of SARS-CoV-2 From Dogs to Hamsters and Pathological Changes in the Brain Article 10.1002/jmv.70496 1 Journal of Medical Virology, v.97, no.7 Journal of Medical Virology 97 7 N scie scopus 001530257700001 2-s2.0-105011202941 Virology Virology Article SARS coronavirus, virus classification infection horizontal transmission, epidemiology