Ko, Eun Ji Hong, Seong-Min Hwang, Hoseong Kwon, Jaeyoung Kwon, Hak Cheol Kim, Sun Yeou 2025-07-30T08:00:17Z 2025-07-30T08:00:17Z 2025-07-28 2025-07 1976-9148 https://pubs.kist.re.kr/handle/201004/152893 Depressive amnesia, involving memory impairment and mood dysregulation, frequently co-occurs with depression and neurodegenerative diseases. Methylglyoxal (MGO), a reactive glycolytic byproduct, contributes to depressive-like behaviors and cognitive deficits. This study evaluated the therapeutic potential of 2',4',6'-trimethoxyacetophenone (TMA), a bioactive compound from Lycoris sanguinea var. koreana, in a mouse model of MGO-induced depressive amnesia. Mice received MGO (60 mg/kg) followed by TMA (5 or 20 mg/kg), and behavioral tests were conducted to assess mood, cognition, and locomotor activity. TMA significantly reduced immobility in tail suspension and forced swim tests, improved locomotion and exploration in the open field, and restored memory in novel object recognition and Y-maze tests. Histological analysis showed that TMA preserved hippocampal integrity, modulated glucocorticoid receptor expression, and reduced cortisol levels, indicating involvement in stress regulation. TMA also attenuated neuroinflammation by lowering IL-1 beta and microglial activation while increasing IL-10. Additionally, it reduced amyloidogenic markers, including oligomeric A beta and amyloid precursor protein. These findings highlight the neuroprotective and antidepressant potential of TMA and support its use as a natural therapeutic candidate for treating depression-related cognitive impairment. English 한국응용약물학회 2',4',6'-Trimethoxyacetophenone Isolated from Lycoris sanguinea Ameliorates Memory Impairment in Methylglyoxal-Induced Depressive Amnesia Mouse Model Article 10.4062/biomolther.2025.065 1 Biomolecules & Therapeutics, v.33, no.4, pp.594 - 605 Biomolecules & Therapeutics 33 4 594 605 N scie scopus kci ART003219551 001526555800004 Biochemistry & Molecular Biology Pharmacology & Pharmacy Biochemistry & Molecular Biology Pharmacology & Pharmacy Article AMYLOID-BETA STRESS LPS Depression Methylglyoxal 2&apos ,4&apos ,6&apos -Trimethoxyacetophenone Neuroinflammation Amyloid pathology Neuroinflammation Lycoris sanguinea var. koreana