Choi, Sung-Geun Kim, Seongchan Kim, Joon-Woo Choi, Myung-Kyun Han, Jieun Koo, Dong-Jun Lee, Soo-Hwan Kim, Aejin Gu, Ji-Woo Kim, Ki Hun Lee, Ju-Yong Bae, Jae-Young Kim, Sung-Yon Kim, Jeonghyun Lee, Hyojin Kang, Seung-Kyun 2025-07-30T09:00:23Z 2025-07-30T09:00:23Z 2025-07-28 2025-07 https://pubs.kist.re.kr/handle/201004/152903 Drug localization, release control, and penetration into solid tissues through biological tight junctions are crucial for the treatment of localized diseases with biological barriers by maximizing therapeutic efficacy of the drug and minimizing damage to normal organs. Here, we introduce a dual-phoretic wireless drug delivery system that harnesses the physical control of ion transportation: electrophoresis for controllable release and iontophoresis for directional penetration. Adjustable, pulsatile, and repeatable drug release under biological conditions is achieved using ion diodes and Zn-based electrochemical cells. Through seamless integration with iontophoretic compartments, a fourfold improvement in delivery efficiency compared to drug diffusion, reaching the core of in vivo tumor, is verified by a 3D tomographic analysis. Fully implantable and wireless operation in a simulated 2-week therapeutic scenario results in a remarkable 50% tumor reduction from the initial volume while minimizing damage to nearby normal tissue and off-target organs such as the heart, liver, spleen, and kidney. English American Association for the Advancement of Science Dual-phoretic wireless device for directionally oriented and carrier-free targeted drug delivery Article 10.1126/sciadv.ads9269 1 Science Advances, v.11, no.28 Science Advances 11 28 Y scie scopus 001525278400023 2-s2.0-105010975061 Multidisciplinary Sciences Science & Technology - Other Topics Article MEMBRANES IN-VIVO TRANSPORT