Hong, Sung-Chul Kim, Jin-Woo Lee, Eun Ha Hong, Chi Rac Choi, Jaeyoung Chang, Pahn-Shick Kim, Jin-Chul 2025-08-20T06:40:39Z 2025-08-20T06:40:39Z 2025-08-20 2025-10 0921-8971 https://pubs.kist.re.kr/handle/201004/152995 Dry eye syndrome (DES) is a prevalent condition that causes corneal damage and discomfort due to dryness. This study investigates Tetraselmis chuii, a novel food ingredient rich in polyunsaturated fatty acids (PUFAs) and carotenoids, for its potential role in DES prevention. Using a scopolamine-induced DES model in BALB/c mice, T. chuii administration increased corneal thickness and tear volume while reducing lacrimal gland tissue damage. Additionally, it inhibited immune cell infiltration in conjunctival and lacrimal gland tissue in a dose-dependent manner, suggesting a reduction in immune cell migration and activation. Western blot and RNA sequencing analyses showed that T. chuii suppressed pro-inflammatory cytokines and immune cell migration markers, modulating inflammation and immune-related gene expression. These results indicate that T. chuii supports ocular health by reducing inflammation and regulating immune responses, making it a promising natural therapeutic for DES treatment and prevention. English Kluwer Academic Publishers Mechanism of dry eye syndrome improvement by Tetraselmis chuii: Anti-inflammatory effects and ocular mucous membrane restoration Article 10.1007/s10811-025-03598-7 1 Journal of Applied Phycology, v.37, no.5, pp.3865 - 3880 Journal of Applied Phycology 37 5 3865 3880 N scie scopus 001537851200001 Biotechnology & Applied Microbiology Marine & Freshwater Biology Biotechnology & Applied Microbiology Marine & Freshwater Biology Article MICROALGAE INFLAMMATION EXPRESSION BIODIESEL DIAGNOSIS EFFICACY IMPACT ACID TREATMENT PRACTICE PATTERN GUIDELINES DISEASE Dry eye syndrome Anti-inflammatory Microalgae Polyunsaturated fatty acids Tetraselmis chuii Chlorophyceae