Park, Hyewon Choi, Wonseok Kim, Hyeongmin Youn, In chan Choi, Yeonho Han, Sungmin 2025-09-29T02:00:13Z 2025-09-29T02:00:13Z 2025-09-22 2025-05-09 https://pubs.kist.re.kr/handle/201004/153250 Histotripsy is a non-invasive therapeutic technique that fragments soft tissue through cavitation-induced mechanical stress. While two-stage approaches have recently gained attention for enhancing control over ablation precision, the relationship between thermal preconditioning and lesion morphology remains underexplored. In this study, we investigate a two-stage histotripsy using a single-frequency (3.5 MHz) ultrasound. The pulse sequence included stage 1 heating of varying durations (5.5, 10, or 16 seconds), followed by stage 2 mechanical ablation. As the stage 1 duration increased, ablated regions were formed toward the transducer's surface and gradually lost their trailing structures. Our findings suggest that lesion formation in the two- stage histotripsy can be affected by tuning thermal exposure duration. Korean 대한의용생체공학회 Analysis of Ablated Lesions In Two-Stage Ultrasound Depending on Heating Duration 2단계 초음파 자극 중 열적 자극 시간 변화에 따른 병변 모양 분석 Conference 2 2025년도 제65회 대한의용생체공학회 춘계학술대회 2025년도 제65회 대한의용생체공학회 춘계학술대회 KO 제주도 롯데 호텔(중문) 2025-05-08 2025년도 제65회 대한의용생체공학회 춘계학술대회