이재욱 2025-10-01T11:31:46Z 2025-10-01T11:31:46Z 2025-09-30 2025-09 1226-6531 https://pubs.kist.re.kr/handle/201004/153317 The key intermediate 5 of the AB-CHMINACA metabolite M2 was synthesized through a sequence of alkylation, hydrolysis, and amide coupling reactions, affording a moderate yield. In particular, the compound 2 and its regioisomer 3 were distingushed by Nuclear Overhouse Effect (NOE) experiments. In the NOE analysis, compound 3 show no NOE correlation between the methylene (CH2) and the aromatic proton, whereas compound 2 exhibited a pronounced NOE effect. The unambiguous identification of compound 2 was crucial for the synthesis of the AB-CHMINACA metabolite M2. The resulting sy nthetic metabolite will serve as a reference standard compound for the detection of illicit drugs. English 한국자기공명학회 Synthesis of Intermediates of AB-CHMINACA metabolite M2 Article 10.6564/JKMRS.2025.29.3.040 2 Journal of the Korean Magnetic Resonance Society, v.29, no.3, pp.40 - 43 Journal of the Korean Magnetic Resonance Society 29 3 40 43 N kci ART003244539 Y SCRAs Cannabinoid receptor NOE 1D NMR