Kim, YO Leem, K Park, J Lee, P Ahn, DK Lee, BC Park, Ho Koon Suk, K Kim, SY Kim, H 2025-11-06T11:01:25Z 2025-11-06T11:01:25Z 2022-04-05 2001-10 0378-8741 https://pubs.kist.re.kr/handle/201004/153426 Based on the use of Scutellaria baicalensis for the treatment of stroke in traditional Oriental medicine, the current study was carried out to evaluate neuroprotective effects of S. baicalensis after transient global ischemia using rat 4-vessel occlusion model. Methanol extracts from the dried roots of S. baicalensis (0.1-10 mg/kg) administered intra-peritoneally significantly protected CAI neurons against 10 min transient forebrain ischemia as demonstrated by measuring the density of neuronal cells stained with Cresyl violet. Methanol extract of S. baicalensis inhibited microglial tumor necrosis factor-alpha (TNF-alpha) and nitric oxide production, and protected PC12 cells from hydrogen peroxide-induced toxicity in vitro. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved. English Elsevier BV Cytoprotective effect of Scutellaria baicalensis in CA1 hippocampal neurons of rats after global cerebral ischemia Article 10.1016/S0378-8741(01)00283-5 1 Journal of Ethnopharmacology, v.77, no.2-3, pp.183 - 188 Journal of Ethnopharmacology 77 2-3 183 188 N scie scopus 000171245700007 2-s2.0-0034882904 Plant Sciences Chemistry, Medicinal Integrative & Complementary Medicine Pharmacology & Pharmacy Plant Sciences Pharmacology & Pharmacy Integrative & Complementary Medicine Article NERVOUS-SYSTEM STROKE INJURY VULNERABILITY CYTOKINES MICROGLIA RADICALS NITRIC-OXIDE Scutellaria baicalensis ischemia TNF-alpha neuroprotection