Ho, Phuong Ly Tran, Son Hung Song, Dae-Geun Lee, Jin I. Kim, Han Sung Kwon, Hak Cheol Kang, Kyungsu 2025-11-12T02:34:08Z 2025-11-12T02:34:08Z 2025-11-11 2025-10 2468-0834 https://pubs.kist.re.kr/handle/201004/153442 Although space exploration has immense untapped potential, the harsh conditions of outer space pose severe threats to the physiological and mental health of astronauts. Microgravity and space radiation can have a multitude of biological effects, ranging from adverse physiological changes to alterations in gene expression. Therefore, increasing amounts of biological research are urgently needed to devise countermeasures for the astronauts during long-term space missions. In space biology research, Caenorhabditis elegans (C. elegans) offers several advantages over other animal models because of its small size, short lifespan, genetic traceability, and lack of ethical complications. In this review, we summarize the equipment and space research conducted thus far using C. elegans. Several biological alterations caused by environmental conditions in space have been identified, such as genomic, epigenomic, metabolic, muscular and neuromuscular, immunological, neuronal, and longevity changes, thus highlighting the applicability of C. elegans as a model organism. In addition, we explore the feasibility of integrating chemical analysis into space research, as well as incorporating biopharmaceuticals and nutraceuticals in the treatment of spaceflight-associated disorders. English 한국응용생명화학회 Caenorhabditis elegans: a tiny model animal for space biology research Article 10.1186/s13765-025-01042-5 1 Applied Biological Chemistry, v.68, no.1 Applied Biological Chemistry 68 1 Y scie scopus kci ART003254605 001585061200001 2-s2.0-105018030554 Food Science & Technology Food Science & Technology Review SIMULATED MICROGRAVITY SPACEFLIGHT RADIATION STRESS RECEPTOR SYSTEM CELLS TOXICITY IMMUNITY GENE-EXPRESSION Microgravity SANS Space biology Spaceflight Space radiation <italic>C. elegans</italic>