Han, Won Bae Han, Sungkeun Shewale, Prashant Shivaji Cho, Hyewon Kim, Li-Hyun Naganaboina, Venkata Ramesh Hwang, Suk-Won 2025-11-26T10:33:38Z 2025-11-26T10:33:38Z 2025-11-26 2026-03 https://pubs.kist.re.kr/handle/201004/153686 Biodegradable adhesives, unlike their traditional counterparts, are engineered to bond to biological tissues while naturally degraded over time, thereby eliminating the need for removal procedures and reducing the risk of chronic inflammation. These unique features are particularly suitable for temporary biomedical applications such as wound closure, internal sealing, or integration with electronics for active/passive functions. The adhesive performance arises from the strategic combination of biodegradable polymers and adhesion mechanisms that dynamically interact with tissue surfaces. This review introduces recent advancements in biodegradable adhesives through a mechanism-based framework, focusing on five key adhesion strategies: physical interlocking, hydrogen bonding, catechol chemistry, amine-carboxyl coupling, and covalent bonding via diazirine or isocyanate linkages. For each strategy, representative material systems, functional properties, and biomedical implementations that enable strong, conformal adhesion under wet and physiological environments are highlighted, and with a discussion of current challenges and future directions toward intelligent, multifunctional bioadhesives for clinical uses are concluded. English Wiley-VCH Verlag Biodegradable Adhesive Systems for Bio-Integrated Applications Article 10.1002/advs.202512633 1 Advanced Science, v.13, no.15 Advanced Science 13 15 Y scie scopus 001617343400001 Chemistry, Multidisciplinary Nanoscience & Nanotechnology Materials Science, Multidisciplinary Chemistry Science & Technology - Other Topics Materials Science Review BIOADHESIVE TISSUES adhesives biodegradable bioelectronics biomedical applications wound closure