Sang Nguyen Qui Ngoc Lee, Heesu Lee, Jae Wook 2025-11-27T11:00:36Z 2025-11-27T11:00:36Z 2025-11-27 2025-09 1226-7155 https://pubs.kist.re.kr/handle/201004/153703 Autophagy is a ubiquitous and fundamental catabolic vital process for maintaining cellular homeostasis, achieved by degrading and recycling cytoplasmic components, particularly under conditions of nutrient deprivation or metabolic stress. This mechanism is also integral to the selective clearance of misfolded or aggregated proteins, the removal of dysfunctional organelles (such as mitochondria and the endoplasmic reticulum), and the intracellular degradation of pathogens, including those associated with peroxisomes. In this study, we screened and identified sesamin, a bioactive compound isolated from Hypericum hookerianum extracts, as a novel autophagy activator. Our results demonstrated that sesamin effectively induces autophagy and activates the lysosome biogenesis pathway. English 대한구강생물학회 Sesamin isolated from Hypericum hookerianum induces autophagy activation Article 10.11620/IJOB.2025.50.3.103 2 International Journal of Oral Biology, v.50, no.3, pp.103 - 111 International Journal of Oral Biology 50 3 103 111 N kci other ART003249279 Y Sesamin Hypericum hookerianum Autophagy