Lim, Donghwan Kim, Jaehoo Kim, Tae Young Kwon, Jiwon Kim, Jaewoo Seo, Jungmok Jang, Yong Hoon Cha, Sung Woon Yoon, Jun Young 2025-12-19T07:00:59Z 2025-12-19T07:00:59Z 2025-12-19 2025-12 1944-8244 https://pubs.kist.re.kr/handle/201004/153804 The fabrication of smart biomaterials that can perform precisely controlled multifunctional tasks in vivo is a significant and challenging goal in therapeutic medicine. Therefore, a remotely actuated, multifunctional smart biocomposite was fabricated herein using Ni–Ti alloy (Nitinol) and poly(methyl methacrylate) (PMMA). The Nitinol–PMMA composite achieved three distinct functions: shape morphing, microcellular foaming, and drug release. Under a noncontact electromagnetic field, the smart biocomposite underwent simultaneous preprogrammed shape morphing due to the heating of Nitinol and microcellular foaming in the carbon dioxide (CO2)-saturated PMMA. This foaming enhanced the impact strength of the composite by 143% and enabled the controlled release of preloaded agents such as sodium benzoate (NaBz) from the PMMA matrix. The potential of the Nitinol–PMMA composite for vascular clamping was confirmed in an in vitro environment, wherein it exhibited excellent cytocompatibility with NIH 3T3 fibroblasts. The kinetic analysis of NaBz release using the Korsmeyer–Peppas model confirmed that the drug release was governed by a quasi-Fickian mechanism correlated to the porosity of the material. This remotely actuated system that integrates actuation, microbubble control, and customized therapy via tailored drug delivery represents a promising paradigm for the development of minimally invasive medical devices. English American Chemical Society A Remotely Actuated Multifunctional Nitinol–PMMA Smart Biocomposite: Microcellular Foaming, Shape Morphing, and Controlled Drug Release Article 10.1021/acsami.5c19771 1 ACS Applied Materials & Interfaces, v.17, no.51, pp.70047 - 70058 ACS Applied Materials & Interfaces 17 51 70047 70058 N scie scopus 001634134100001 Nanoscience & Nanotechnology Materials Science, Multidisciplinary Science & Technology - Other Topics Materials Science Article MECHANICAL-PROPERTIES CARBON-DIOXIDE TEMPERATURE ALLOY smart biocomposites shape morphing drug release microcellularfoaming process electromagnetic induction