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Hindy, George Ho, Yuk-Lam Hofer, Edith Holliday, Elizabeth Horn, Katrin Hornsby, Whitney E. Hottenga, Jouke-Jan Huang, Hongyan Huang, Jie Huerta-Chagoya, Alicia Huo, Shaofeng Hwang, Mi Yeong Hwu, Chii-Min Iha, Hiroyuki Ikeda, Daisuke D. Isono, Masato Jackson, Anne U. Jansen, Iris E. Jiang, Yunxuan Johansson, Ingegerd Jonsson, Anna Jorgensen, Torben Kalafati, Ioanna P. Kanai, Masahiro Kanoni, Stavroula Karhus, Line L. Kasturiratne, Anuradhani Katsuya, Tomohiro Kawaguchi, Takahisa Kember, Rachel L. Kentistou, Katherine A. Kim, Daeeun Kim, Han-Na Kim, Young Jin Kleber, Marcus E. Knol, Maria J. Kurbasic, Azra Lauzon, Marie Le, Phuong Lea, Rodney Lee, Jong-Young Lee, Wen-Jane Leonard, Hampton L. Li, Hengtong Li, Shengchao A. 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Riveros, Carlos Rohde, Rebecca Ruggiero, Daniela Ruotsalainen, Sanni E. Ryan, Kathleen A. Sabater-Lleal, Maria Santin, Aurora Saxena, Richa Scholz, Markus Shen, Botong Shi, Jingchunzi Shin, Jae Hun Sidore, Carlo Sidorenko, Julia Sim, Xueling Slieker, Roderick C. Smith, Albert V. Smith, Jennifer A. Smyth, Laura J. Southam, Lorraine Steinthorsdottir, Valgerdur Sun, Liang Takeuchi, Fumihiko Taylor, Kent D. Tayo, Bamidele O. Tcheandjieu, Catherine Terzikhan, Natalie Tesolin, Paola Teumer, Alexander Theusch, Elizabeth Thompson, Deborah J. Thorleifsson, Gudmar Timmers, Paul R. H. J. Trompet, Stella Turman, Constance Vaccargiu, Simona van der Laan, Sander W. van der Most, Peter J. van Klinken, Jan B. van Setten, Jessica Verma, Shefali S. Verweij, Niek Veturi, Yogasudha Wang, Carol A. Wang, Chaolong Wang, Jun-Sing Wang, Lihua Wang, Ya Xing Wang, Zhe Warren, Helen R. Wei, Wen Bin Wen, Wanqing Wheeler, William A. Wickremasinghe, Ananda R. Wielscher, Matthias Winsvold, Bendik S. Wong, Andrew Wuttke, Matthias Xia, Rui Yamamoto, Ken Yang, Jingyun Yao, Jie Young, Hannah Yousri, Noha A. Yu, Lei Zeng, Lingyao Zhang, Weihua Zhang, Xinyuan Zhao, Jing-Hua Zhao, Wei Zhou, Wei Zimmermann, Martina E. Zoledziewska, Magdalena 't Hart, Leen M. Adair, Linda S. Adams, Hieab H. H. Aguilar-Salinas, Carlos A. Al-Mulla, Fahd Arnett, Donna K. Asselbergs, Folkert W. Asvold, Bjorn Olav Attia, John Banas, Bernhard Bandinelli, Stefania Beilin, Lawrence J. Bennett, David A. Bergler, Tobias Bharadwaj, Dwaipayan Biino, Ginevra Boerwinkle, Eric Boeger, Carsten A. Borja, Judith B. Bouchard, Claude Bowden, Donald W. Brandslund, Ivan Ben Brumpton Buring, Julie E. Caulfield, Mark J. Chambers, John C. Chandak, Giriraj R. Chanock, Stephen J. Chaturvedi, Nish Chen, Yii-Der Ida Chen, Zhengming Cheng, Ching-Yu Cho, Yoon Shin Christensen, Kaare Christophersen, Ingrid E. Ciullo, Marina Cole, John W. Collins, Francis S. Concas, Maria Pina Cooper, Richard S. 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Stark, Klaus J. Strachan, David P. Tabara, Yasuharu Tai, E. Shyong Tang, Hua Tardif, Jean-Claude Thanaraj, Thangavel A. Toenjes, Anke Tuomi, Tiinamaija Tuomilehto, Jaakko Tusie-Luna, Maria-Teresa van Dam, Rob M. van der Harst, Pim van der Velde, Nathalie van Duijn, Cornelia M. van Schoor, Natasja M. Vitart, Veronique Vohl, Marie-Claude Voelker, Uwe Vollenweider, Peter Voelzke, Henry Vrieze, Scott Wacher-Rodarte, Niels H. Walker, Mark Wander, Gurpreet S. Wareham, Nicholas J. Watanabe, Richard M. Watkins, Hugh Weir, David R. Werge, Thomas M. Widen, Elisabeth Willemsen, Gonneke Willett, Walter C. Wilson, James F. Wilson, Peter W. F. Wong, Tien Y. Woo, Jeong-Taek Wright, Alan F. Xu, Huichun Yajnik, Chittaranjan S. Yang, Jian Yokota, Mitsuhiro Yuan, Jian-Min Zeggini, Eleftheria Zemel, Babette S. Zheng, Wei Zhu, Xiaofeng Zillikens, M. Carola Zonderman, Alan B. Zwart, John-Anker Abecasis, Goncalo R. Assimes, Themistocles L. Auton, Adam Boehnke, Michael Chasman, Daniel I. Esko, Tonu Stefansson, Kari Lettre, Guillaume Lindgren, Cecilia M. Ng, Maggie C. Y. O'Donnell, Christopher J. Thorsteinsdottir, Unnur Visscher, Peter M. Walters, Robin G. Winkler, Thomas W. Wood, Andrew R. Deloukas, Panos Frayling, Timothy M. Justice, Anne E. Kilpelainen, Tuomas O. Locke, Adam E. Mohlke, Karen L. North, Kari E. Okada, Yukinori Willer, Cristen J. Young, Kristin L. Fatumo, Segun McCaffery, Jeanne M. Timpson, Nicholas J. Hirschhorn, Joel N. Sun, Yan V. Berndt, Sonja I. Loos, Ruth J. F. 2025-12-23T03:00:19Z 2025-12-23T03:00:19Z 2025-12-19 2025-09 1078-8956 https://pubs.kist.re.kr/handle/201004/153845 Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry. For other populations, this ranged from 16% in East Asian-Americans to 2.2% in rural Ugandans. In the ALSPAC study, children with higher PGSs showed accelerated BMI gain from age 2.5 years to adolescence, with earlier adiposity rebound. Adding the PGS to predictors available at birth nearly doubled explained variance for BMI from age 5 onward (for example, from 11% to 21% at age 8). Up to age 5, adding the PGS to early-life BMI improved prediction of BMI at age 18 (for example, from 22% to 35% at age 5). Higher PGSs were associated with greater adult weight gain. In intensive lifestyle intervention trials, individuals with higher PGSs lost modestly more weight in the first year (0.55 kg per s.d.) but were more likely to regain it. Overall, these data show that PGSs have the potential to improve obesity prediction, particularly when implemented early in life. English Nature Publishing Group Polygenic prediction of body mass index and obesity through the life course and across ancestries Article 10.1038/s41591-025-03827-z 1 Nature Medicine, v.31, no.9, pp.3151 - + Nature Medicine 31 9 3151 + Y scie scopus 001589396000001 2-s2.0-105014329108 Biochemistry & Molecular Biology Cell Biology Medicine, Research & Experimental Biochemistry & Molecular Biology Cell Biology Research & Experimental Medicine Article RESOURCE DIABETES PREVENTION PROGRAM WEIGHT-LOSS STYLE INTERVENTION GENETIC RISK ADIPOSITY HEALTH CHILDHOOD ASSOCIATIONS OVERWEIGHT