Moon, Jihwan Park, Hana Cho, Yoeseph Hwang, Sungmin Oh, Seung-Yun Heo, Jung-Seok Jung, Hyungil Son, Junghyun 2025-12-30T02:00:08Z 2025-12-30T02:00:08Z 2025-11-24 2025-11-21 https://pubs.kist.re.kr/handle/201004/153914 With the rapid rise of drug crimes in South Korea and the emergence of over 900 new psychoactive substances (NPS), conventional forensic analysis has reached its practical limits. This study introduces a portable vapor-phase drug detection kit integrated with a colorimetric metal–organic framework (MOF) sensor array and AI-assisted imaging analysis for rapid, on-site screening. Unlike conventional liquid-based methods that require laboratory instrumentation and long processing times, the proposed platform directly detects vaporized drug particles in real time without complex preparation. The MOF array exhibited distinct and reproducible color transitions across 54 tested drugs, demonstrating excellent sensitivity and durability. Quantitative RGB pattern analysis revealed group-specific optical responses: Amphetamine-, Cathinone-, MDxx-, and Benzofuran-class compounds shared a characteristic decrease in G values and increase in B values, while non-phenethylamine and heterocyclic tropane groups displayed unique, independent RGB patterns. These findings indicate that phenethylamine-type structures exhibit consistent chromatic signatures, enabling structural classification through colorimetric data. This technology provides a field-deployable, non-destructive, and customizable drug detection platform for forensic and law-enforcement applications, with future potential in breath-based diagnostics, environmental monitoring, and food-safety testing. English The Korean Society of Analytical Sciences Enhanced Detection of narcotics Using Vapor-Phase Analysis from Rapid Drug Test Kits: Paving the Way for Breath-Based Diagnostics Conference 2 제75회 한국분석과학회 추계 학술대회 (The 75th Biannual Conference for The Korean Society of Analytical Sciences) 제75회 한국분석과학회 추계 학술대회 (The 75th Biannual Conference for The Korean Society of Analytical Sciences) KO The K Hotel (경주) 2025-11-19 제75 회 한국분석과학회 추계 학술대회 초록집