Shin, Yangji Nho, Chu Won 2025-12-30T02:00:38Z 2025-12-30T02:00:38Z 2025-11-25 2025-09-30 https://pubs.kist.re.kr/handle/201004/153918 Epigenetic alteration is considered a crucial factor contributing to the development of various chronic diseases such as cancer, aging, and metabolic disorders. While dysregulated epigenetic modifications can exacerbate diseases, their reversible properties make them attractive targets for drug development. Natural compounds offer an invaluable resource for drug discovery. In contrast to synthetic chemicals, they are often less toxic, more biocompatible and pleiotropic, affecting multiple targets. In this context, we focused on identifying novel natural compounds that act as epigenetic modulators. We screened 46 natural compounds to determine the ability to deplete DNA methyltransferase 1 (DNMT1) expression. Five promising compounds decreased the protein level of DNMT1 in a dose-dependent manner. It suggests these compounds may be associated with DNA methylation through interactions with DNMT1 and other linked epigenetic factors. Further studies are needed to understand how these compounds regulate DNMT1 protein expression. These natural compounds have the potential to reverse abnormal epigenetic marks, re-activate silenced genes, and restore normal cellular functions. English 한국분자세포생물학회 Screening of natural compounds for epigenetic regulation via DNMT1 suppression Conference 1 KSMCB 2025 international conference KSMCB 2025 international conference KO 제주, 대한민국 2025-09-29 ICKSMCB 2025 Poster Abstract