Kim, Seo Jin Cha, Yeon Kyung Kim, Kyung Ho Kim, Gyeong-Ji Seo, Sung Eun Kim, Jung In Kim, Jae Hyeon Lee, Yeon Kyung Seo, Minah Ryu, Yong-Sang Kim, Se-Hong Lee, Kyoung G. Song, Hyun Seok Kwon, Oh Seok 2026-02-03T05:00:05Z 2026-02-03T05:00:05Z 2026-01-12 2026-03 0956-5663 https://pubs.kist.re.kr/handle/201004/154104 Schizophrenia remains challenging to diagnose objectively, as conventional assessments rely on subjective symptom evaluation and are often associated with significant diagnostic delays. In this study, we present a portable, multiplexed graphene field-effect transistor (GFET) biosensor array for the simultaneous and ultrasensitive detection of three schizophrenia-related biomarkers-cortisol, serotonin, and dopamine-at femtomolar concentrations. Fabricated using microelectromechanical systems processes, the array integrates three monolayer graphene channels on a single chip, each covalently functionalized with a specific bioreceptor to ensure high selectivity and minimal cross-reactivity. Real-time monitoring of transfer characteristics enables detection via Dirac point shifts induced by bioreceptor-analyte binding. The GFET platform demonstrates femtomolar-level sensitivity, broad dynamic range, and specificity in both phosphate-buffered saline and artificial serum. Moreover, the system supports real-time, Bluetooth-enabled data transmission, offering a rapid and objective point-of-care tool to complement conventional psychiatric diagnostics. This platform holds promise for reducing diagnostic latency, supporting personalized treatment strategies, and advancing precision mental health care. English Pergamon Press Ltd. High-performance graphene field-effect transistor platform for on-site schizophrenia-related biomarkers detection Article 10.1016/j.bios.2025.118321 1 Biosensors and Bioelectronics, v.296 Biosensors and Bioelectronics 296 N scie scopus 001650410500001 2-s2.0-105025428355 Biophysics Biotechnology & Applied Microbiology Chemistry, Analytical Electrochemistry Nanoscience & Nanotechnology Biophysics Biotechnology & Applied Microbiology Chemistry Electrochemistry Science & Technology - Other Topics Article SPECTROSCOPY Schizophrenia Multiplexed detection On-chip device Graphene field-effect transistor Point-of-care