Lee, Yunjung Kim, Youngjoon Kwon, Seokjun Park, Ok Kyu Min, Gyeong Ho Chu, Jinyoung Kim, Yubeen Yoon, Johyun Lee, Hyochul Kim, Hojun Soh, Min Lee, Nohyun Jeon, Hojeong Kim, Yu-chan Kim, Junchul Yeo, Ki Baek Choi, Seung Hong Jun, Sang Ho Lee, Yuhan Hyeon, Taeghwan Lee, Sang-woo Han, Sang Ihn 2026-02-03T07:00:38Z 2026-02-03T07:00:38Z 2026-02-02 2026-01 0935-9648 https://pubs.kist.re.kr/handle/201004/154135 Oral delivery of therapeutic nanoparticles offers a non-invasive approach for treating gastrointestinal diseases, but achieving localized and sustained mucosal exposure while avoiding systemic toxicity remains a major challenge. Here, a Sucralfate-based oral formulation is developed that incorporates therapeutic nanoparticles and transforms into a paste-like coacervate upon contact with intestinal fluid, uniformly coating the entire gastrointestinal tract within 6 h, and clearing through fecal transit by 12 h. Systematic investigation shows that nanoparticle hydrophobicity is essential for stable incorporation into Sucralfate-based formulation, supporting compatibility with a wide range of nanoparticle types. The incorporated nanoparticles are stabilized by strong non-covalent interactions, which limit gastric leaching and reduce cellular uptake by 0.044% compared with PEGylated nanoparticles. As a representative example, antioxidant cerium oxide nanoparticles are tested in two distinct oxidative stress-related models of intestinal injury, including immune-mediated colitis and radiation-induced enteropathy. In DSS colitis, our system reduced weight loss from 17.2% to 2.2% and restored colon structure and oxidative-stress injury. In radiation-induced enteropathy, our system attenuated weight loss from 25.5% to 11.4%, doubled villus length, and markedly enhanced epithelial regeneration. The formulation also accommodates nanoparticles with imaging capability, demonstrating versatility for both therapeutic and diagnostic applications in gastrointestinal diseases. English WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Orally Administered Nanoparticle Coacervate for Therapeutic Coating of Full Gastrointestinal Tract Article 10.1002/adma.202514708 1 Advanced Materials Advanced Materials N scie 2-s2.0-105026507959 Chemistry, Multidisciplinary Chemistry, Physical Nanoscience & Nanotechnology Materials Science, Multidisciplinary Physics, Applied Physics, Condensed Matter Chemistry Science & Technology - Other Topics Materials Science Physics Article; Early Access EXTRACELLULAR-MATRIX CERIA NANOPARTICLES DRUG-DELIVERY RADIATION NANOMATERIALS ACID cerium oxide nanoparticles inflammatory bowel diseases intestinal lining oral delivery radiation-induced enteritis sucralfate