Shamsizadeh, Mohammad Amir Movahed, Siyavash Kazemi Bahreini, Zahra Chae, Keun Hwa Khuzani, Ali Habibi 2026-02-04T05:30:33Z 2026-02-04T05:30:33Z 2026-02-02 2026-04 1293-2558 https://pubs.kist.re.kr/handle/201004/154186 Natural enzymes, despite their high efficiency, suffer from instability and high costs, limiting their practical use. Nanozymes which are nanomaterial-based enzyme mimics offer a robust alternative. Here, we report the design and synthesis of a bimetallic nanozyme consisting of iron and ruthenium nanoparticles that are immobilized on ordered mesoporous carbon spheres (FeRu@OMCS). This nanozyme exhibits exceptional peroxidase-like activity driven by a synergistic electronic interaction between the two metals. X-ray photoelectron spectroscopy shows charge transfer from ruthenium to iron and demonstrates this interaction. The FeRu@OMCS nanozyme has an outstandingly low Michaelis-Menten constant (Km) of 0.043 mM with the substrate tetramethylbenzidine (TMB), indicating a higher affinity for the substrate than that of its monometallic counterparts and even natural horseradish peroxidase. This work presents a rational design strategy for creating highly active, stable, and cost-effective bimetallic nanozymes for potential applications in diagnostics and catalysis. English Elsevier BV Iron-ruthenium nanoparticles on ordered mesoporous carbon: A bimetallic nanozyme with superior peroxidase-like activity Article 10.1016/j.solidstatesciences.2026.108210 1 Solid State Sciences, v.174 Solid State Sciences 174 N scie scopus 001659965200001 2-s2.0-105026656189 Chemistry, Inorganic & Nuclear Chemistry, Physical Physics, Condensed Matter Chemistry Physics Article ARTIFICIAL ENZYMES HYDROGEN-PEROXIDE OXYGEN GOLD Nanozyme Peroxidase Bimetallic Ruthenium Iron