Kim, Hojun 2026-04-16T07:00:13Z 2026-04-16T07:00:13Z 2026-04-14 2026-03 1225-5475 https://pubs.kist.re.kr/handle/201004/154568 Self-assembled lipid mesophases are gaining attention as versatile platforms for biosensing. Their polymorphic forms—including lamellar, hexagonal, and bicontinuous cubic phases—offer nanoscale architectures with distinct transport, mechanical, and optical characteristics. These structures can preserve the activity of biomolecules, facilitate efficient charge and mass transfer, and provide membrane-like interfaces for the detection of biomolecules, including metabolites, nucleic acids, proteins, and viruses. This review summarizes the fundamental principles of lipid mesophase formation and examines how their properties can be tuned by altering composition, introducing polymers or nanoparticles, or applying external stimuli. We further highlight recent advances in their use for electrochemical, optical, and affinity-based biosensing. We also discuss current limitations related to reproducibility, stability, and device integration, and identify opportunities in rational design, hybrid systems, and portable or implantable platforms. Overall, engineered lipid mesophases hold significant potential as foundations for next-generation biosensors that unite sensitivity, selectivity, and practical usability. English 한국센서학회 Engineering Lipid Mesophases for Biosensors Article 10.46670/jsst.2026.35.2.136 1 Journal of Sensor Science and Technology, v.35, no.2, pp.136 - 147 Journal of Sensor Science and Technology 35 2 136 147 N scopus kci Lipid mesophase Self-assembly Biosensors Cubic phase Nanostructured materials Electrochemical and optical sensing